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Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
Zhou, Zhigui; Zhang, Jialing; Zhang, Wei; Bai, Yu; Liu, Huwei
刊名ANALYST
2011
DOI10.1039/c0an01047b
136期:12页:2613-2618
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; ELECTROSPRAY-IONIZATION ; SULFONYLUREA-TYPE ; ION-SOURCE ; METFORMIN ; QUANTIFICATION ; IDENTIFICATION ; ROSIGLITAZONE ; GLIBENCLAMIDE
英文摘要Adulteration of herbal supplements with synthetic drugs is illegal. A rapid and reliable method which utilizes direct analysis in real time mass spectrometry (DART-MS) was developed for the identification of seven synthetic antidiabetic drugs used as adulterants in herbal dietary supplements. The supplement sample was simply extracted with methanol/water by manually shaking several times and directly analyzed using DART-MS. The presence of synthetic drug adulterants was confirmed through the accurate m/z values and MS/MS data obtained via quadruple time of flight mass spectrometry (QTOF MS). Parameters for the DART source were systematically optimized, and the limits of detection (LODs) in herbal supplement matrices were measured. This method was successfully applied to examine five commercial herbal dietary supplements, and two of them proved to be adulterated with metformin without labeling.
语种英语
WOS记录号WOS:000291164900025
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142559
专题中国科学院大连化学物理研究所
作者单位Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Inst Analyt Chem,Minist Educ, Beijing 100871, Peoples R China
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GB/T 7714
Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,et al. Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry[J]. ANALYST,2011,136(12):2613-2618.
APA Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,Bai, Yu,&Liu, Huwei.(2011).Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry.ANALYST,136(12),2613-2618.
MLA Zhou, Zhigui,et al."Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry".ANALYST 136.12(2011):2613-2618.
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