DICP OpenIR
Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
Zhou, Zhigui; Zhang, Jialing; Zhang, Wei; Bai, Yu; Liu, Huwei
Source PublicationANALYST
2011
DOI10.1039/c0an01047b
Volume136Issue:12Pages:2613-2618
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; ELECTROSPRAY-IONIZATION ; SULFONYLUREA-TYPE ; ION-SOURCE ; METFORMIN ; QUANTIFICATION ; IDENTIFICATION ; ROSIGLITAZONE ; GLIBENCLAMIDE
AbstractAdulteration of herbal supplements with synthetic drugs is illegal. A rapid and reliable method which utilizes direct analysis in real time mass spectrometry (DART-MS) was developed for the identification of seven synthetic antidiabetic drugs used as adulterants in herbal dietary supplements. The supplement sample was simply extracted with methanol/water by manually shaking several times and directly analyzed using DART-MS. The presence of synthetic drug adulterants was confirmed through the accurate m/z values and MS/MS data obtained via quadruple time of flight mass spectrometry (QTOF MS). Parameters for the DART source were systematically optimized, and the limits of detection (LODs) in herbal supplement matrices were measured. This method was successfully applied to examine five commercial herbal dietary supplements, and two of them proved to be adulterated with metformin without labeling.
Language英语
WOS IDWOS:000291164900025
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142559
Collection中国科学院大连化学物理研究所
AffiliationPeking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Inst Analyt Chem,Minist Educ, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,et al. Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry[J]. ANALYST,2011,136(12):2613-2618.
APA Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,Bai, Yu,&Liu, Huwei.(2011).Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry.ANALYST,136(12),2613-2618.
MLA Zhou, Zhigui,et al."Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry".ANALYST 136.12(2011):2613-2618.
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