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题名: Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
作者: Zhou, Zhigui1;  Zhang, Jialing1;  Zhang, Wei1;  Bai, Yu1;  Liu, Huwei1
刊名: ANALYST
发表日期: 2011
DOI: 10.1039/c0an01047b
卷: 136, 期:12, 页:2613-2618
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Adulteration of herbal supplements with synthetic drugs is illegal. A rapid and reliable method which utilizes direct analysis in real time mass spectrometry (DART-MS) was developed for the identification of seven synthetic antidiabetic drugs used as adulterants in herbal dietary supplements. The supplement sample was simply extracted with methanol/water by manually shaking several times and directly analyzed using DART-MS. The presence of synthetic drug adulterants was confirmed through the accurate m/z values and MS/MS data obtained via quadruple time of flight mass spectrometry (QTOF MS). Parameters for the DART source were systematically optimized, and the limits of detection (LODs) in herbal supplement matrices were measured. This method was successfully applied to examine five commercial herbal dietary supplements, and two of them proved to be adulterated with metformin without labeling.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  HUMAN PLASMA ;  ELECTROSPRAY-IONIZATION ;  SULFONYLUREA-TYPE ;  ION-SOURCE ;  METFORMIN ;  QUANTIFICATION ;  IDENTIFICATION ;  ROSIGLITAZONE ;  GLIBENCLAMIDE
语种: 英语
WOS记录号: WOS:000291164900025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142559
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Inst Analyt Chem,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,et al. Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry[J]. ANALYST,2011,136(12):2613-2618.
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