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题名: Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib
作者: Dong, Pei-pei1, 2;  Fang, Zhong-ze1, 2;  Zhang, Yan-yan1;  Ge, Guang-bo1;  Mao, Yu-xi1, 2;  Zhu, Liang-liang1, 2;  Qu, Yan-qing3;  Li, Wei1, 2;  Wang, Li-ming3;  Liu, Chang-xiao4;  Yang, Ling1
关键词: erlotinib ;  CYP isoform ;  human liver microsomes ;  substrate-dependent inhibition (or modulation) ;  drug interaction
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2011-03-01
DOI: 10.1038/aps.2010.218
卷: 32, 期:3, 页:399-407
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Aim: To ascertain the effects of erlotinib on CYP3A, to investigate the amplitude and kinetics of erlotinib-mediated inhibition of seven major CYP isoforms in human liver microsomes (HLMs) for evaluating the magnitude of erlotinib in drug-drug interaction in vivo.
关键词[WOS]: HUMAN CYTOCHROME-P450 ENZYMES ;  DRUG-DRUG INTERACTIONS ;  CELL LUNG-CANCER ;  RECEPTOR TYROSINE KINASE ;  ADVANCED SOLID TUMORS ;  IN-VITRO DATA ;  LIVER-MICROSOMES ;  PHASE-I ;  METABOLISM ;  INHIBITION
语种: 英语
WOS记录号: WOS:000288003200017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142569
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116027, Peoples R China
4.Tianjin Inst Pharmaceut Res, Tianjin Key Lab Pharmacokinet & Clin Pharmacol, Tianjin 300193, Peoples R China

Recommended Citation:
Dong, Pei-pei,Fang, Zhong-ze,Zhang, Yan-yan,et al. Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib[J]. ACTA PHARMACOLOGICA SINICA,2011,32(3):399-407.
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