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Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment
Huang, Shuqiang1,2; Lin, Bingcheng1; Qin, Jianhua1
关键词Microfluidics Peg Poly(N-isopropylacrylamide) Microparticle Porous Tunable
刊名ELECTROPHORESIS
2011-11-01
DOI10.1002/elps.201100340
32期:23页:3364-3370
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]VOLUME-PHASE-TRANSITION ; POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS ; THERMORESPONSIVE MICROGELS ; N-ISOPROPYLACRYLAMIDE ; DRUG-DELIVERY ; KINETICS ; MICROSPHERES ; PARTICLES ; RELEASE ; NANOPARTICLES
英文摘要We present a microfluidic droplet method to synthesize a series of tunable poly(N-isopropylacrylamide) (PNIPAM) microparticles by the addition of polyethylene glycols (PEGs). The PEGs are used as porogens and could be removed simply by washing step. By varying molecular weights and concentrations of the PEGs, morphologies and temperature-sensitive properties of the formed PNIPAM microparticles are flexibly tuned. It is found that PEG of lower molecular weight induces smaller micropore sizes, and results in faster response rate. The volume changes prior to and after shrinkage can also be regulated by the addition of PEGs due to tuned homogeneities of micropores. The microparticles tuned by PEG1000 with ratio of added PEGs to NIPAM of 2:1 respond the fastest (120?s), whereas with ratio of added PEGs to NIPAM of 1:1 display largest volume change (1/?=12.12). This simplicity and controllability of tunable microparticles synthesis are appealing for various applications ranging from chemical delivery, drug release control, to optical applications.
语种英语
WOS记录号WOS:000298300900008
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142570
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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GB/T 7714
Huang, Shuqiang,Lin, Bingcheng,Qin, Jianhua. Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment[J]. ELECTROPHORESIS,2011,32(23):3364-3370.
APA Huang, Shuqiang,Lin, Bingcheng,&Qin, Jianhua.(2011).Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment.ELECTROPHORESIS,32(23),3364-3370.
MLA Huang, Shuqiang,et al."Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment".ELECTROPHORESIS 32.23(2011):3364-3370.
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