DICP OpenIR
Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment
Huang, Shuqiang1,2; Lin, Bingcheng1; Qin, Jianhua1
KeywordMicrofluidics Peg Poly(N-isopropylacrylamide) Microparticle Porous Tunable
Source PublicationELECTROPHORESIS
2011-11-01
DOI10.1002/elps.201100340
Volume32Issue:23Pages:3364-3370
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordVOLUME-PHASE-TRANSITION ; POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS ; THERMORESPONSIVE MICROGELS ; N-ISOPROPYLACRYLAMIDE ; DRUG-DELIVERY ; KINETICS ; MICROSPHERES ; PARTICLES ; RELEASE ; NANOPARTICLES
AbstractWe present a microfluidic droplet method to synthesize a series of tunable poly(N-isopropylacrylamide) (PNIPAM) microparticles by the addition of polyethylene glycols (PEGs). The PEGs are used as porogens and could be removed simply by washing step. By varying molecular weights and concentrations of the PEGs, morphologies and temperature-sensitive properties of the formed PNIPAM microparticles are flexibly tuned. It is found that PEG of lower molecular weight induces smaller micropore sizes, and results in faster response rate. The volume changes prior to and after shrinkage can also be regulated by the addition of PEGs due to tuned homogeneities of micropores. The microparticles tuned by PEG1000 with ratio of added PEGs to NIPAM of 2:1 respond the fastest (120?s), whereas with ratio of added PEGs to NIPAM of 1:1 display largest volume change (1/?=12.12). This simplicity and controllability of tunable microparticles synthesis are appealing for various applications ranging from chemical delivery, drug release control, to optical applications.
Language英语
WOS IDWOS:000298300900008
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142570
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Huang, Shuqiang,Lin, Bingcheng,Qin, Jianhua. Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment[J]. ELECTROPHORESIS,2011,32(23):3364-3370.
APA Huang, Shuqiang,Lin, Bingcheng,&Qin, Jianhua.(2011).Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment.ELECTROPHORESIS,32(23),3364-3370.
MLA Huang, Shuqiang,et al."Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment".ELECTROPHORESIS 32.23(2011):3364-3370.
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