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题名: Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment
作者: Huang, Shuqiang1, 2;  Lin, Bingcheng1;  Qin, Jianhua1
关键词: Microfluidics ;  PEG ;  Poly(N-isopropylacrylamide) microparticle ;  Porous ;  Tunable
刊名: ELECTROPHORESIS
发表日期: 2011-11-01
DOI: 10.1002/elps.201100340
卷: 32, 期:23, 页:3364-3370
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: We present a microfluidic droplet method to synthesize a series of tunable poly(N-isopropylacrylamide) (PNIPAM) microparticles by the addition of polyethylene glycols (PEGs). The PEGs are used as porogens and could be removed simply by washing step. By varying molecular weights and concentrations of the PEGs, morphologies and temperature-sensitive properties of the formed PNIPAM microparticles are flexibly tuned. It is found that PEG of lower molecular weight induces smaller micropore sizes, and results in faster response rate. The volume changes prior to and after shrinkage can also be regulated by the addition of PEGs due to tuned homogeneities of micropores. The microparticles tuned by PEG1000 with ratio of added PEGs to NIPAM of 2:1 respond the fastest (120?s), whereas with ratio of added PEGs to NIPAM of 1:1 display largest volume change (1/?=12.12). This simplicity and controllability of tunable microparticles synthesis are appealing for various applications ranging from chemical delivery, drug release control, to optical applications.
关键词[WOS]: VOLUME-PHASE-TRANSITION ;  POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS ;  THERMORESPONSIVE MICROGELS ;  N-ISOPROPYLACRYLAMIDE ;  DRUG-DELIVERY ;  KINETICS ;  MICROSPHERES ;  PARTICLES ;  RELEASE ;  NANOPARTICLES
语种: 英语
WOS记录号: WOS:000298300900008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142570
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Huang, Shuqiang,Lin, Bingcheng,Qin, Jianhua. Microfluidic synthesis of tunable poly-(N-isopropylacrylamide) microparticles via PEG adjustment[J]. ELECTROPHORESIS,2011,32(23):3364-3370.
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