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题名: Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases
作者: Liu, Kun-hui1;  Wu, Li-dan1;  Zou, Xiao-ran1;  Yang, Wen1;  Du, Qian1;  Su, Hong-mei1
关键词: Tetrachlorobenzoquinone ;  Thymine ;  Uracil ;  Triplet state ;  Hydrogen abstraction ;  Electron transfer ;  Laser flash photolysis
刊名: CHINESE JOURNAL OF CHEMICAL PHYSICS
发表日期: 2011-10-01
DOI: 10.1088/1674-0068/24/05/580-585
卷: 24, 期:5, 页:580-585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Physics, Atomic, Molecular & Chemical
研究领域[WOS]: Physics
英文摘要: Pentachlorophenol, a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone (TCBQ) which can result in DNA damage. We have investigated the photochemical. reaction dynamics of TCBQ with two pyrimidine type nucleobases (thymine and uracil) upon UVA (355 nm) excitation using the technique of nanosecond time-resolved laser flash photolysis. It has been found that 355 nm excitation populates TCBQ molecules to their triplet state (3)TCBQ*, which are highly reactive towards thymine or uracil and undergo two parallel reactions, the hydrogen abstraction and electron transfer, leading to the observed photoproducts of TCBQH. and TCBQ.(-) in transient absorption spectra. The concomitantly produced nucleobase radicals and radical cations are expected to induce a series of oxidative or strand cleavage damage to DNA afterwards. By characterizing the photochemical hydrogen abstraction and electron transfer reactions, our results provide potentially important molecular reaction mechanisms for understanding the carcinogenic effects of pentachlorophenol and its metabolites TCBQ.
关键词[WOS]: LASER FLASH-PHOTOLYSIS ;  RADICAL CATIONS ;  TRIPLET-STATE ;  DNA ;  PENTACHLOROPHENOL ;  CHLORANIL ;  QUINONES ;  GUANINE ;  CARCINOGENESIS ;  TOXICOLOGY
语种: 英语
WOS记录号: WOS:000297139200012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142639
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China

Recommended Citation:
Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,et al. Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases[J]. CHINESE JOURNAL OF CHEMICAL PHYSICS,2011,24(5):580-585.
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