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题名: Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
作者: Ma, Pan1, 2;  Liu, Hong-Tao1;  Wei, Peng1, 2;  Xu, Qing-Song1;  Bai, Xue-Fang1;  Du, Yu-Guang1;  Yu, Chao3
关键词: Chitosan oligomers ;  Inflammation ;  Mitogen-activated protein kinase ;  Phosphatidylinositol 3-kinase ;  Macrophage cells
刊名: CARBOHYDRATE POLYMERS
发表日期: 2011-04-02
DOI: 10.1016/j.carbpol.2011.01.045
卷: 84, 期:4, 页:1391-1398
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitosan oligomers show various biological activities. However, its molecular mechanisms remain unknown in LPS-stimulated macrophages. Here, we explored the inhibitive effects of chitosan oligomers on LPS-induced IL-6/TNF-alpha production in macrophages. The results indicated chitosan oligomers pretreatment effectively inhibited LPS-induced over-expression of both inflammatory cytokines. Signal transduction studies show chitosan oligomers may repress not only the phosphorylation of p38, ERK1/2, JNK, phosphatidylinositol 3-kinase (PI3K) and Akt, but also the activation of nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1). Furthermore, both the activation of NF-kappa B/AP-1 and the subsequent IL-6/TNF-alpha over-expression in LPS-induced macrophages are inhibited by specific p38 inhibitor (SB203580), ERK1/2 inhibitor (PD98059), JNK inhibitor (SP600125) and PI3K inhibitor (LY294002). In conclusion, our investigation suggests chitosan oligomers inhibited the elevated expression of IL-6/TNF-alpha in LPS-induced macrophages, regulated by MAPKs and PI3K/Akt pathways dependent on NF-kappa B/AP-1 activation. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: NF-KAPPA-B ;  TUMOR-NECROSIS-FACTOR ;  GENE-EXPRESSION ;  ENDOTHELIAL-CELLS ;  INDUCED CYTOKINE ;  CHITOOLIGOSACCHARIDES ;  P38 ;  INFLAMMATION ;  PHOSPHORYLATION ;  INACTIVATION
语种: 英语
WOS记录号: WOS:000289123300026
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142644
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China
3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China

Recommended Citation:
Ma, Pan,Liu, Hong-Tao,Wei, Peng,et al. Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways[J]. CARBOHYDRATE POLYMERS,2011,84(4):1391-1398.
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