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Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
Ma, Pan1,2; Liu, Hong-Tao1; Wei, Peng1,2; Xu, Qing-Song1; Bai, Xue-Fang1; Du, Yu-Guang1; Yu, Chao3
关键词Chitosan Oligomers Inflammation Mitogen-activated Protein Kinase Phosphatidylinositol 3-kinase Macrophage Cells
刊名CARBOHYDRATE POLYMERS
2011-04-02
DOI10.1016/j.carbpol.2011.01.045
84期:4页:1391-1398
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; GENE-EXPRESSION ; ENDOTHELIAL-CELLS ; INDUCED CYTOKINE ; CHITOOLIGOSACCHARIDES ; P38 ; INFLAMMATION ; PHOSPHORYLATION ; INACTIVATION
英文摘要Chitosan oligomers show various biological activities. However, its molecular mechanisms remain unknown in LPS-stimulated macrophages. Here, we explored the inhibitive effects of chitosan oligomers on LPS-induced IL-6/TNF-alpha production in macrophages. The results indicated chitosan oligomers pretreatment effectively inhibited LPS-induced over-expression of both inflammatory cytokines. Signal transduction studies show chitosan oligomers may repress not only the phosphorylation of p38, ERK1/2, JNK, phosphatidylinositol 3-kinase (PI3K) and Akt, but also the activation of nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1). Furthermore, both the activation of NF-kappa B/AP-1 and the subsequent IL-6/TNF-alpha over-expression in LPS-induced macrophages are inhibited by specific p38 inhibitor (SB203580), ERK1/2 inhibitor (PD98059), JNK inhibitor (SP600125) and PI3K inhibitor (LY294002). In conclusion, our investigation suggests chitosan oligomers inhibited the elevated expression of IL-6/TNF-alpha in LPS-induced macrophages, regulated by MAPKs and PI3K/Akt pathways dependent on NF-kappa B/AP-1 activation. (C) 2011 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000289123300026
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142644
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China
3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
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Ma, Pan,Liu, Hong-Tao,Wei, Peng,et al. Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways[J]. CARBOHYDRATE POLYMERS,2011,84(4):1391-1398.
APA Ma, Pan.,Liu, Hong-Tao.,Wei, Peng.,Xu, Qing-Song.,Bai, Xue-Fang.,...&Yu, Chao.(2011).Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways.CARBOHYDRATE POLYMERS,84(4),1391-1398.
MLA Ma, Pan,et al."Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways".CARBOHYDRATE POLYMERS 84.4(2011):1391-1398.
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