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Synthesis of Isoquinolines via Rhodium(III)-Catalyzed Dehydrative C-C and C-N Coupling between Oximines and Alkynes
Zhang, Xingping1,2; Chen, Dan2,3; Zhao, Miao2; Zhao, Jing1; Jia, Aiqun3; Li, Xingwei2
KeywordAlkynes Arenes Isoquinolines Oximines Rhodium Catalysis
Source PublicationADVANCED SYNTHESIS & CATALYSIS
2011-03-28
DOI10.1002/adsc.201000887
Volume353Issue:5Pages:719-723
Indexed BySCI ; IC ; CCR
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS Research AreaChemistry
WOS KeywordPALLADIUM-CATALYZED IMINOANNULATION ; H BOND-CLEAVAGE ; INTERNAL ALKYNES ; TERMINAL ACETYLENES ; AROMATIC KETIMINES ; DIRECT ARYLATION ; ASTERISK-IR ; ACTIVATION ; DERIVATIVES ; PYRIDINES
AbstractIsoquinolines have been synthesized from the redox-neutral dehydrative C-N and C-C cross-coupling between oximines and alkynes using a catalytic amount of (pentamethylcyclopentadiene)rhodium dichloride dimer {[RhCp*Cl-2](2)} and cesium acetate (CsOAc), a process that involves ortho C-H activation of oximines and subsequent functionalization with alkynes. This redox-neutral catalytic isoquinoline synthesis operates under mild conditions, and is insensitive to moisture or air. A broad scope of coupling partners has been established, and a likely mechanism has been suggested.
Language英语
WOS IDWOS:000288701600008
Citation statistics
Cited Times:177[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142653
Collection中国科学院大连化学物理研究所
Affiliation1.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210014, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xingping,Chen, Dan,Zhao, Miao,et al. Synthesis of Isoquinolines via Rhodium(III)-Catalyzed Dehydrative C-C and C-N Coupling between Oximines and Alkynes[J]. ADVANCED SYNTHESIS & CATALYSIS,2011,353(5):719-723.
APA Zhang, Xingping,Chen, Dan,Zhao, Miao,Zhao, Jing,Jia, Aiqun,&Li, Xingwei.(2011).Synthesis of Isoquinolines via Rhodium(III)-Catalyzed Dehydrative C-C and C-N Coupling between Oximines and Alkynes.ADVANCED SYNTHESIS & CATALYSIS,353(5),719-723.
MLA Zhang, Xingping,et al."Synthesis of Isoquinolines via Rhodium(III)-Catalyzed Dehydrative C-C and C-N Coupling between Oximines and Alkynes".ADVANCED SYNTHESIS & CATALYSIS 353.5(2011):719-723.
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