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题名: Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway
作者: Fang, Zhong-Ze1, 2;  Nian, Yin2, 3;  Li, Wei1, 2;  Wu, Jing-Jing1;  Ge, Guang-Bo1, 2;  Dong, Pei-Pei1, 2;  Zhang, Yan-Yan1, 2;  Qiu, Ming-Hua3;  Liu, Lei4;  Yang, Ling1
关键词: cycloartane triterpenoids ;  MCF7 ;  p53 ;  apoptosis ;  mitochondrial membrane potential ;  caspase-7
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2011
DOI: 10.1002/ptr.3222
卷: 25, 期:1, 页:17-24
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
关键词[WOS]: EXTRACT INHIBITS PROLIFERATION ;  CYTOTOXICITY ;  CONSTITUENTS ;  GLYCOSIDES ;  DAHURICA ;  RHIZOMA
语种: 英语
WOS记录号: WOS:000285848700003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142676
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China

Recommended Citation:
Fang, Zhong-Ze,Nian, Yin,Li, Wei,et al. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway[J]. PHYTOTHERAPY RESEARCH,2011,25(1):17-24.
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