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Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway
Fang, Zhong-Ze1,2; Nian, Yin2,3; Li, Wei1,2; Wu, Jing-Jing1; Ge, Guang-Bo1,2; Dong, Pei-Pei1,2; Zhang, Yan-Yan1,2; Qiu, Ming-Hua3; Liu, Lei4; Yang, Ling1
关键词Cycloartane Triterpenoids Mcf7 P53 Apoptosis Mitochondrial Membrane Potential Caspase-7
刊名PHYTOTHERAPY RESEARCH
2011
DOI10.1002/ptr.3222
25期:1页:17-24
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]EXTRACT INHIBITS PROLIFERATION ; CYTOTOXICITY ; CONSTITUENTS ; GLYCOSIDES ; DAHURICA ; RHIZOMA
英文摘要The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-beta-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-beta-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-alpha-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside (compound 5). The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. The involvement of apoptosis as a major cause of cycloartane triterpenoids-induced cell death was further confirmed. The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
语种英语
WOS记录号WOS:000285848700003
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142676
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Shenzhen Childrens Hosp, Shenzhen 518100, Peoples R China
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Fang, Zhong-Ze,Nian, Yin,Li, Wei,et al. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway[J]. PHYTOTHERAPY RESEARCH,2011,25(1):17-24.
APA Fang, Zhong-Ze.,Nian, Yin.,Li, Wei.,Wu, Jing-Jing.,Ge, Guang-Bo.,...&Yang, Ling.(2011).Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway.PHYTOTHERAPY RESEARCH,25(1),17-24.
MLA Fang, Zhong-Ze,et al."Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway".PHYTOTHERAPY RESEARCH 25.1(2011):17-24.
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