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题名: An enantioselective synthesis of 3-aryl-4-phosphonobutyric acid esters via Cu-catalyzed asymmetric conjugate reduction
作者: Guo, Wei-Lei1, 2;  Hou, Chuan-Jin1;  Duan, Zheng-Chao2;  Hu, Xiang-Ping2
刊名: TETRAHEDRON-ASYMMETRY
发表日期: 2011-12-31
DOI: 10.1016/j.tetasy.2011.12.009
卷: 22, 期:24, 页:2161-2164
收录类别: SCI ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Inorganic & Nuclear ;  Chemistry, Organic ;  Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: The asymmetric conjugate reduction of 3-aryl-4-phosphonobutenoates has been demonstrated which provides an enantioselective synthesis of optically active 3-aryl-4-phosphonobutyric acid esters. A wide range of 3-aryl-4-phosphonobutenoate derivates are reduced with high enantioselectivities (up to 94% ee) using an (S)-Segphos/Cu(OAc)(2)center dot H2O catalyst system (1 or 5 mol %) in the presence of PMHS and t-BuOH. The reduction is influenced by the steric and electronic effects of the substrates. (C) 2012 Elsevier Ltd. All rights reserved.
关键词[WOS]: DYNAMIC KINETIC-RESOLUTION ;  BOPHOZ-TYPE LIGAND ;  ALPHA,BETA-UNSATURATED ESTERS ;  DIASTEREOSELECTIVE SYNTHESIS ;  HYDROGENATION ;  PHOSPHONATES ;  DERIVATIVES ;  INHIBITORS ;  HYDROXYPHOSPHONATES ;  HYDROSILYLATIONS
语种: 英语
WOS记录号: WOS:000301892700014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142684
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Polytech Univ, Sch Light Ind & Chem Engn, Dalian 116034, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Guo, Wei-Lei,Hou, Chuan-Jin,Duan, Zheng-Chao,et al. An enantioselective synthesis of 3-aryl-4-phosphonobutyric acid esters via Cu-catalyzed asymmetric conjugate reduction[J]. TETRAHEDRON-ASYMMETRY,2011,22(24):2161-2164.
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