DICP OpenIR
Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots
Chang, Wen-Te1; Choi, Young Hae2; Van der Heijden, Rob3; Lee, Meng-Shiou1; Lin, Ming-Kuem1; Kong, Hongwei3,4; Kim, Hye Kyong2; Verpoorte, Robert2; Hankemeier, Thomas3; Van der Greef, Jan3,5; Wang, Mei5,6
关键词Rehmannia Glutinosa Traditional Processing Fourier-transform-mass Spectrometry Principle Component Analysis
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2011-05-01
59期:5页:546-552
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]NUCLEAR-MAGNETIC-RESONANCE ; ABSOLUTE STEREOSTRUCTURES ; IRIDOID GLYCOSIDES ; QUALITY-CONTROL ; DIABETIC-RATS ; RADIX ; SPECTROSCOPY ; CONSTITUENTS ; LIBOSCH ; POLYSACCHARIDES
英文摘要The processing of biological raw materials is considered to have an important role in the therapeutic application in Traditional Chinese Medicine. The root of Rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in clinical applications. In order to understand the chemical changes resulting from the processing, a comprehensive analysis of Rehmanniae radix was made using H-1-NMR and Fourier transform (FT)-mass spectrometry in combination with multivariate data analysis. After H-1-NMR and principle component analysis, hydrolysis was found to be the major chemical process during the treatments. Catalpol, raffinose and stachyose levels gradually decreased during processing, whereas monosaccharides including galactose and glucose were found to be higher in processed roots. The metabolic profile changed gradually through the processing cycles although the differences became smaller after the fifth processing cycle. The positive and negative ion-mode mass spectra by high resolution FT-MS revealed several series of ion clusters with mass differences of 162.053 Da, indicating a difference of a hexose moiety. During the processing, the number and signal intensity of the smaller glycosides were increased. Therefore, these results indicate that the fresh Rehmanniae radix is rich in polysaccharides, which are hydrolyzed during the processing.
语种英语
WOS记录号WOS:000290194400004
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142729
专题中国科学院大连化学物理研究所
作者单位1.China Med Univ, Sch Chinese Med Resources, Taichung 40402, Taiwan
2.Leiden Univ, Inst Biol, Sect Metabol, Div Pharmacognosy, NL-2300 RA Leiden, Netherlands
3.Leiden Amsterdam Ctr Drug Res, Ctr Med Syst Biol, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
5.SU BioMed, NL-3700 AJ Zeist, Netherlands
6.TNO Qual Life, Dept Appl Plant Sci, NL-2333 CK Leiden, Netherlands
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GB/T 7714
Chang, Wen-Te,Choi, Young Hae,Van der Heijden, Rob,et al. Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(5):546-552.
APA Chang, Wen-Te.,Choi, Young Hae.,Van der Heijden, Rob.,Lee, Meng-Shiou.,Lin, Ming-Kuem.,...&Wang, Mei.(2011).Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots.CHEMICAL & PHARMACEUTICAL BULLETIN,59(5),546-552.
MLA Chang, Wen-Te,et al."Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots".CHEMICAL & PHARMACEUTICAL BULLETIN 59.5(2011):546-552.
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