中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots
作者: Chang, Wen-Te1;  Choi, Young Hae2;  Van der Heijden, Rob3;  Lee, Meng-Shiou1;  Lin, Ming-Kuem1;  Kong, Hongwei3, 4;  Kim, Hye Kyong2;  Verpoorte, Robert2;  Hankemeier, Thomas3;  Van der Greef, Jan3, 5;  Wang, Mei5, 6
关键词: Rehmannia glutinosa ;  traditional processing ;  Fourier-transform-mass spectrometry ;  principle component analysis
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2011-05-01
卷: 59, 期:5, 页:546-552
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: The processing of biological raw materials is considered to have an important role in the therapeutic application in Traditional Chinese Medicine. The root of Rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in clinical applications. In order to understand the chemical changes resulting from the processing, a comprehensive analysis of Rehmanniae radix was made using H-1-NMR and Fourier transform (FT)-mass spectrometry in combination with multivariate data analysis. After H-1-NMR and principle component analysis, hydrolysis was found to be the major chemical process during the treatments. Catalpol, raffinose and stachyose levels gradually decreased during processing, whereas monosaccharides including galactose and glucose were found to be higher in processed roots. The metabolic profile changed gradually through the processing cycles although the differences became smaller after the fifth processing cycle. The positive and negative ion-mode mass spectra by high resolution FT-MS revealed several series of ion clusters with mass differences of 162.053 Da, indicating a difference of a hexose moiety. During the processing, the number and signal intensity of the smaller glycosides were increased. Therefore, these results indicate that the fresh Rehmanniae radix is rich in polysaccharides, which are hydrolyzed during the processing.
关键词[WOS]: NUCLEAR-MAGNETIC-RESONANCE ;  ABSOLUTE STEREOSTRUCTURES ;  IRIDOID GLYCOSIDES ;  QUALITY-CONTROL ;  DIABETIC-RATS ;  RADIX ;  SPECTROSCOPY ;  CONSTITUENTS ;  LIBOSCH ;  POLYSACCHARIDES
语种: 英语
WOS记录号: WOS:000290194400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142729
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Med Univ, Sch Chinese Med Resources, Taichung 40402, Taiwan
2.Leiden Univ, Inst Biol, Sect Metabol, Div Pharmacognosy, NL-2300 RA Leiden, Netherlands
3.Leiden Amsterdam Ctr Drug Res, Ctr Med Syst Biol, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
5.SU BioMed, NL-3700 AJ Zeist, Netherlands
6.TNO Qual Life, Dept Appl Plant Sci, NL-2333 CK Leiden, Netherlands

Recommended Citation:
Chang, Wen-Te,Choi, Young Hae,Van der Heijden, Rob,et al. Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2011,59(5):546-552.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Chang, Wen-Te]'s Articles
 [Choi, Young Hae]'s Articles
 [Van der Heijden, Rob]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Chang, Wen-Te]‘s Articles
 [Choi, Young Hae]‘s Articles
 [Van der Heijden, Rob]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace