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题名: Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice
作者: Cui, Yong2, 3, 4, 5;  Sun, Guang-wei1, 3;  Yamashita, Daisuke2, 3;  Kanzaki, Sho2;  Matsunaga, Tatsuo3;  Fujii, Masato3;  Kaga, Kimitaka3;  Ogawa, Kaoru2
关键词: Spiral limbus ;  Fibrocytes ;  Noise ;  Hearing loss
刊名: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
发表日期: 2011-07-01
DOI: 10.1007/s00405-011-1484-3
卷: 268, 期:7, 页:973-978
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Otorhinolaryngology
研究领域[WOS]: Otorhinolaryngology
英文摘要: Fibrocytes of the spiral limbus are thought to play a significant role in maintaining ion homeostasis in the cochlea. The present study measured physiological and morphological changes in spiral limbus of mice in response to noise exposure. 6-week-old male C3H/HeJJcl mice were exposed to octave-band noise (120 dB SPL) for 2 h and evaluated at a series of times thereafter, up to 8 weeks. Permanent hearing loss resulted in the mice, as assessed by auditory brainstem response (ABR) recordings. The fibrocytes loss was found in the spiral limbus of the apical turn, which has been proved to be induced by apoptosis. These results suggest that noise exposure might result in apoptosis of fibrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss.
关键词[WOS]: INDUCED HEARING-LOSS ;  LATERAL WALL ;  THRESHOLD SHIFT ;  MOUSE COCHLEA ;  NOISE EXPOSURE ;  HAIR-CELLS ;  TRAUMA ;  CA2+-ATPASE ;  TEMPORARY ;  NEURONS
语种: 英语
WOS记录号: WOS:000291170400005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142731
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Keio Univ, Sch Med, Dept Otolaryngol, Shinjuku Ku, Tokyo 1608582, Japan
3.Natl Tokyo Med Ctr, Natl Inst Sensory Organs, Div Hearing & Balance Res, Lab Auditory Disorders,Meguro Ku, Tokyo 1528902, Japan
4.Guangdong Acad Med Sci, Dept Otolaryngol, Guangzhou 510080, Guangdong, Peoples R China
5.Guangdong Gen Hosp, Guangzhou 510080, Guangdong, Peoples R China

Recommended Citation:
Cui, Yong,Sun, Guang-wei,Yamashita, Daisuke,et al. Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice[J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY,2011,268(7):973-978.
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