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题名: Separation of enantiomers of drugs by capillary electrophoresis .4. Hydroxypropyl-gamma-cyclodextrin as chiral solvating agent
作者: Koppenhoefer, B;  Epperlein, U;  Zhu, XF;  Lin, BC
关键词: capillary electrophoresis ;  enantiomer separation ;  chiral drugs ;  hydroxypropyl-gamma-cyclodextrin
刊名: ELECTROPHORESIS
发表日期: 1997-06-01
卷: 18, 期:6, 页:924-930
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.
关键词[WOS]: BETA-CYCLODEXTRIN ;  ELECTROKINETIC CHROMATOGRAPHY ;  ZONE ELECTROPHORESIS ;  RESOLUTION ;  MICELLES ;  MODEL
语种: 英语
WOS记录号: WOS:A1997XH29300011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142804
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.INST CHEM PHYS,DALIAN,PEOPLES R CHINA

Recommended Citation:
Koppenhoefer, B,Epperlein, U,Zhu, XF,et al. Separation of enantiomers of drugs by capillary electrophoresis .4. Hydroxypropyl-gamma-cyclodextrin as chiral solvating agent[J]. ELECTROPHORESIS,1997,18(6):924-930.
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