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Multiparameter evaluation of the longevity in C-elegans under stress using an integrated microfluidic device
Wen, Hui; Shi, Weiwei; Qin, Jianhua
关键词Microfluidic C. Elegans Longevity Polydatin
刊名BIOMEDICAL MICRODEVICES
2012-08-01
DOI10.1007/s10544-012-9652-9
14期:4页:721-728
收录类别SCI
文章类型Article
类目[WOS]Engineering, Biomedical ; Nanoscience & Nanotechnology
研究领域[WOS]Engineering ; Science & Technology - Other Topics
英文摘要Caenorhabditis elegans (C. elegans) is an excellent model organism for the study of aging and longevity. In this work, we presented a microfluidic approach for the evaluation of longevity in C. elegans under stress. The microfluidic device integrated multiple microvalves with parallel channels, which enabled the long-term culture and flexible manipulation of C. elegans in real-time. The utility of the device was demonstrated by characterizing the lifespan, mobility behavior and fluorescence expression of oxidative stress in mutant strain CL2166 simultaneously at single animal resolution. A certain dose of polydatin was found to enable the extension of mean lifespan of CL2166 for the first time, and the prolonged longevity activity was possibly mediated by the protective response to oxidative stress, indicating the promising role of polydatin involved in aging process. The device is simple to operate, easy for real-time imaging and multiparatemer evaluations in parallel, providing the powerful platform for drug evaluation/screening in highthroughput format.
语种英语
WOS记录号WOS:000305951500011
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142875
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Wen, Hui,Shi, Weiwei,Qin, Jianhua. Multiparameter evaluation of the longevity in C-elegans under stress using an integrated microfluidic device[J]. BIOMEDICAL MICRODEVICES,2012,14(4):721-728.
APA Wen, Hui,Shi, Weiwei,&Qin, Jianhua.(2012).Multiparameter evaluation of the longevity in C-elegans under stress using an integrated microfluidic device.BIOMEDICAL MICRODEVICES,14(4),721-728.
MLA Wen, Hui,et al."Multiparameter evaluation of the longevity in C-elegans under stress using an integrated microfluidic device".BIOMEDICAL MICRODEVICES 14.4(2012):721-728.
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