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Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro
Wei, Peng1,2; Ma, Pan1,2; Xu, Qing-Song1; Bai, Qun-Hua3; Gu, Jian-Guo4; Xi, Hao5; Du, Yu-Guang1; Yu, Chao3
KeywordChitosan Oligosaccharides Microglial Cell Inflammation Mapks Nf-kappa b Ap-1
Source PublicationGLYCOCONJUGATE JOURNAL
2012-08-01
DOI10.1007/s10719-012-9392-3
Volume29Issue:5-6Pages:285-295
Indexed BySCI
SubtypeArticle
WOS SubjectBiochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordACTIVATED PROTEIN-KINASES ; SIGNALING PATHWAYS ; MANNOSE RECEPTOR ; MAP KINASE ; C-FOS ; EXPRESSION ; INHIBITION ; P38 ; CHITOOLIGOSACCHARIDES ; COMPLEX
AbstractChitosan oligosaccharides (COS) have been reported to exert many biological activities, such as antioxidant, antitumor and anti-inflammatory effects. In the present study, we examined the effect of COS on nitric oxide (NO) production in LPS induced N9 microglial cells. Pretreatment with COS (50 similar to 200 mu g/ml) could markedly inhibit NO production by suppressing inducible nitric oxide synthase (iNOS) expression in activated microglial cells. Signal transduction studies showed that COS remarkably inhibited LPS-induced phosphorylation of p38 MAPK and ERK1/2. COS pretreatment could also inhibit the activation of both nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1). In conclusion, our results suggest that COS could suppress the production of NO in LPS-induced N9 microglial cells, mediated by p38 MAPK and ERK1/2 pathways.
Language英语
WOS IDWOS:000307763900006
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Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142876
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China
3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
4.Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Inst Mol Biomembrane & Glycobiol, Sendai, Miyagi 9818558, Japan
5.Sichuan Univ, Chengdu 610064, Peoples R China
Recommended Citation
GB/T 7714
Wei, Peng,Ma, Pan,Xu, Qing-Song,et al. Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro[J]. GLYCOCONJUGATE JOURNAL,2012,29(5-6):285-295.
APA Wei, Peng.,Ma, Pan.,Xu, Qing-Song.,Bai, Qun-Hua.,Gu, Jian-Guo.,...&Yu, Chao.(2012).Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro.GLYCOCONJUGATE JOURNAL,29(5-6),285-295.
MLA Wei, Peng,et al."Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro".GLYCOCONJUGATE JOURNAL 29.5-6(2012):285-295.
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