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Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro
Wei, Peng1,2; Ma, Pan1,2; Xu, Qing-Song1; Bai, Qun-Hua3; Gu, Jian-Guo4; Xi, Hao5; Du, Yu-Guang1; Yu, Chao3
关键词Chitosan Oligosaccharides Microglial Cell Inflammation Mapks Nf-kappa b Ap-1
刊名GLYCOCONJUGATE JOURNAL
2012-08-01
DOI10.1007/s10719-012-9392-3
29期:5-6页:285-295
收录类别SCI
文章类型Article
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ACTIVATED PROTEIN-KINASES ; SIGNALING PATHWAYS ; MANNOSE RECEPTOR ; MAP KINASE ; C-FOS ; EXPRESSION ; INHIBITION ; P38 ; CHITOOLIGOSACCHARIDES ; COMPLEX
英文摘要Chitosan oligosaccharides (COS) have been reported to exert many biological activities, such as antioxidant, antitumor and anti-inflammatory effects. In the present study, we examined the effect of COS on nitric oxide (NO) production in LPS induced N9 microglial cells. Pretreatment with COS (50 similar to 200 mu g/ml) could markedly inhibit NO production by suppressing inducible nitric oxide synthase (iNOS) expression in activated microglial cells. Signal transduction studies showed that COS remarkably inhibited LPS-induced phosphorylation of p38 MAPK and ERK1/2. COS pretreatment could also inhibit the activation of both nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1). In conclusion, our results suggest that COS could suppress the production of NO in LPS-induced N9 microglial cells, mediated by p38 MAPK and ERK1/2 pathways.
语种英语
WOS记录号WOS:000307763900006
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142876
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China
3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
4.Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Inst Mol Biomembrane & Glycobiol, Sendai, Miyagi 9818558, Japan
5.Sichuan Univ, Chengdu 610064, Peoples R China
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GB/T 7714
Wei, Peng,Ma, Pan,Xu, Qing-Song,et al. Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro[J]. GLYCOCONJUGATE JOURNAL,2012,29(5-6):285-295.
APA Wei, Peng.,Ma, Pan.,Xu, Qing-Song.,Bai, Qun-Hua.,Gu, Jian-Guo.,...&Yu, Chao.(2012).Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro.GLYCOCONJUGATE JOURNAL,29(5-6),285-295.
MLA Wei, Peng,et al."Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro".GLYCOCONJUGATE JOURNAL 29.5-6(2012):285-295.
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