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题名: Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
作者: Liu, Rong1, 2;  Lai, Yusi1;  He, Bin1;  Li, Yuan1;  Wang, Gang1;  Chang, Shuang1;  Gu, Zhongwei1
关键词: polyrotaxane ;  self-assembly ;  nanoparticle ;  doxorubicin ;  supermolecular
刊名: INTERNATIONAL JOURNAL OF NANOMEDICINE
发表日期: 2012
DOI: 10.2147/IJN.S33649
卷: 7, 页:5249-5258
收录类别: SCI
文章类型: Article
类目[WOS]: Nanoscience & Nanotechnology ;  Pharmacology & Pharmacy
研究领域[WOS]: Science & Technology - Other Topics ;  Pharmacology & Pharmacy
英文摘要: A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in alpha-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 mu g/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.
关键词[WOS]: ALPHA-CYCLODEXTRIN ;  POLY(ETHYLENE GLYCOL) ;  INCLUSION COMPLEXES ;  POLYMERIC MICELLES ;  GENE DELIVERY ;  IN-VIVO ;  DOXORUBICIN ;  TUMOR ;  GUEST ;  CANCER
语种: 英语
WOS记录号: WOS:000309445600001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142884
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Liu, Rong,Lai, Yusi,He, Bin,et al. Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2012,7:5249-5258.
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