中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Theories to support method development in comprehensive two-dimensional liquid chromatography - A review
作者: Bedani, Filippo1, 2;  Schoenmakers, Peter J.2;  Janssen, Hans-Gerd2, 3
关键词: Degree of orthogonality ;  First-dimension undersampling ;  LC LC method development ;  LC LC optimization ;  On-line comprehensive two-dimensional liquid chromatography
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2012-07-01
DOI: 10.1002/jssc.201200070
卷: 35, 期:14, 页:1697-1711
收录类别: SCI
文章类型: Review
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: On-line comprehensive two-dimensional liquid chromatography techniques promise to resolve samples that current one-dimensional liquid chromatography methods cannot adequately deal with. To make full use of the potential of two-dimensional liquid chromatography, optimization is required. Optimization of two-dimensional liquid chromatography is a relatively new yet important research topic the aim of which is to predict combinations of stationary and mobile phases, column formats, and chromatographic conditions that maximize resolving power and minimize analysis time. In on-line two-dimensional liquid chromatography, dilution-related issues play also an important role and these should be taken into account when developing optimization strategies. In this work, state-of-the-art strategies that support method development for on-line two-dimensional liquid chromatography through a rigorous choice of chromatographic parameters are critically reviewed. The final aim is to provide practitioners with a clear understanding of which aspects can be optimized using current on-line two-dimensional liquid chromatography strategies (and which ones cannot). In two-dimensional liquid chromatography, maximizing resolving power for a given analysis time and dilution requires optimizing efficiency, selectivity and retention. While great strides forward have been made in the optimization of efficiency-related issues, considerable effort needs still to be made in terms of (1) developing models that can predict the retention factors that given stationary/mobile phase systems can provide and (2) using this information for choosing the two ones that maximize two-dimensional liquid chromatography orthogonality. Because of this limitation, in two-dimensional liquid chromatography, this aspect is typically dealt with a posteriori through examining chromatograms. This review clearly shows that important progress in the optimization of on-line two-dimensional liquid chromatography has recently been made.
关键词[WOS]: HYDROPHOBIC-SUBTRACTION MODEL ;  SINGLE COMPLEX CHROMATOGRAMS ;  REVERSED-PHASE SEPARATIONS ;  PEAK-CAPACITY ;  HIGH-PRESSURE ;  2ND-DIMENSION GRADIENT ;  SYSTEM SELECTIVITY ;  INFORMATION-THEORY ;  STATISTICAL-METHOD ;  STATIONARY PHASES
语种: 英语
WOS记录号: WOS:000306493700001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142918
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Amsterdam, Vant Hoff Inst Mol Sci, Analyt Chem Grp, Amsterdam, Netherlands
3.Unilever Res Labs, Adv Measurement & Data Modelling, Vlaardingen, Netherlands

Recommended Citation:
Bedani, Filippo,Schoenmakers, Peter J.,Janssen, Hans-Gerd. Theories to support method development in comprehensive two-dimensional liquid chromatography - A review[J]. JOURNAL OF SEPARATION SCIENCE,2012,35(14):1697-1711.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Bedani, Filippo]'s Articles
 [Schoenmakers, Peter J.]'s Articles
 [Janssen, Hans-Gerd]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Bedani, Filippo]‘s Articles
 [Schoenmakers, Peter J.]‘s Articles
 [Janssen, Hans-Gerd]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace