中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Biological, Chemical, and Omics Research of Taxus Medicinal Resources
作者: Hao, Da-Cheng1;  Xiao, Pei-Gen1, 2;  Ge, Guang-Bo3;  Liu, Ming1
关键词: Taxus ;  medicinal resource ;  phylogeny and evolution ;  biotechnology ;  phytochemistry ;  omics
刊名: DRUG DEVELOPMENT RESEARCH
发表日期: 2012-12-01
DOI: 10.1002/ddr.21040
卷: 73, 期:8, 页:477-486
收录类别: SCI
文章类型: Article
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Taxus is a botanical source for the anticancer drug taxol (paclitaxel), first reported in 1971 as a result of bioassay guided fractionation of active extracts from stem bark samples of T. brevifolia. This led to additional discoveries of pharmacologically active taxoids in other Taxus species and to investigations on their biosynthetic precursors, analogues, and derivatives. In continuation with our studies on Taxus biochemistry, we review the genomics, transcriptomics, proteomics, metabolomics, and bioinformatics of Taxus and their endophytic fungi. The bibliometric method is used to quantify and characterize the global scientific effort in the omics technologies being applied. We conclude that systems biology and omics technologies will play an increasingly important role in future medical research involving bioactive compounds of Taxus and other natural products. Drug Dev Res 73 : 477-486, 2012. (C) 2012 Wiley Periodicals, Inc.
关键词[WOS]: POSITIVE DARWINIAN SELECTION ;  IONIZATION MASS-SPECTROMETRY ;  CELL-SUSPENSION CULTURES ;  METHYL JASMONATE ;  MOLECULAR EVOLUTION ;  TRANSCRIPTOME ANALYSIS ;  TAXANE PRODUCTION ;  NATURAL-PRODUCTS ;  CUSPIDATA CELLS ;  CHINESE YEW
语种: 英语
WOS记录号: WOS:000314221100003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142921
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Jiaotong Univ, Biotechnol Inst, Sch Environm, Dalian, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Hao, Da-Cheng,Xiao, Pei-Gen,Ge, Guang-Bo,et al. Biological, Chemical, and Omics Research of Taxus Medicinal Resources[J]. DRUG DEVELOPMENT RESEARCH,2012,73(8):477-486.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Hao, Da-Cheng]'s Articles
 [Xiao, Pei-Gen]'s Articles
 [Ge, Guang-Bo]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Hao, Da-Cheng]‘s Articles
 [Xiao, Pei-Gen]‘s Articles
 [Ge, Guang-Bo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace