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题名: Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS
作者: He Fan1, 2;  Dou De-Qiang2;  Sun Yu2;  Zhu Lin3;  Xiao Hong-Bin3;  Kang Ting-Guo1
关键词: arctiin ;  arctigenin ;  HPLC-MS ;  pharmacokinetics ;  tissue distribution ;  Arctium lappa ;  Compositae
刊名: PLANTA MEDICA
发表日期: 2012-05-01
DOI: 10.1055/s-0031-1298433
卷: 78, 期:8, 页:800-806
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main metabolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatographic separation was performed on an Agilent (TM) C-18 HPLC column with acetonitrile and water by linear gradient elution. Arctiin and arctigenin were identified online by LC-MS. The pharmacokinetics and tissue distribution of arctiin and arctigenin were determined for the first time by using a simple, selective, and accurate HPLC method. The AUC(0-t) values of arctigenin were larger compared with arctiin after oral administration of arctiin. The concentration of the metabolite was significantly higher than the concentration of arctiin in the stomach and small intestine in rats after oral administration of arctiin, indicating that the stomach and small intestine were the major organs of arctiin metabolism. These findings could provide support for the clinical studies conducted with Fructus Arctii.
关键词[WOS]: SPRAGUE-DAWLEY RATS ;  TRANSFORMATION ;  ARCTIGENIN ;  LIGNANS ;  MAMMARY ;  L.
语种: 英语
WOS记录号: WOS:000304449300010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142966
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Univ Tradit Chinese Med, Dept Pharmacognosy, Dalian 116600, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Dept Chinese Med Chem, Dalian 116600, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
He Fan,Dou De-Qiang,Sun Yu,et al. Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS[J]. PLANTA MEDICA,2012,78(8):800-806.
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