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Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS
He Fan1,2; Dou De-Qiang2; Sun Yu2; Zhu Lin3; Xiao Hong-Bin3; Kang Ting-Guo1
关键词Arctiin Arctigenin Hplc-ms Pharmacokinetics Tissue Distribution Arctium Lappa Compositae
刊名PLANTA MEDICA
2012-05-01
DOI10.1055/s-0031-1298433
78期:8页:800-806
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]SPRAGUE-DAWLEY RATS ; TRANSFORMATION ; ARCTIGENIN ; LIGNANS ; MAMMARY ; L.
英文摘要The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main metabolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatographic separation was performed on an Agilent (TM) C-18 HPLC column with acetonitrile and water by linear gradient elution. Arctiin and arctigenin were identified online by LC-MS. The pharmacokinetics and tissue distribution of arctiin and arctigenin were determined for the first time by using a simple, selective, and accurate HPLC method. The AUC(0-t) values of arctigenin were larger compared with arctiin after oral administration of arctiin. The concentration of the metabolite was significantly higher than the concentration of arctiin in the stomach and small intestine in rats after oral administration of arctiin, indicating that the stomach and small intestine were the major organs of arctiin metabolism. These findings could provide support for the clinical studies conducted with Fructus Arctii.
语种英语
WOS记录号WOS:000304449300010
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142966
专题中国科学院大连化学物理研究所
作者单位1.Liaoning Univ Tradit Chinese Med, Dept Pharmacognosy, Dalian 116600, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Dept Chinese Med Chem, Dalian 116600, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
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GB/T 7714
He Fan,Dou De-Qiang,Sun Yu,et al. Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS[J]. PLANTA MEDICA,2012,78(8):800-806.
APA He Fan,Dou De-Qiang,Sun Yu,Zhu Lin,Xiao Hong-Bin,&Kang Ting-Guo.(2012).Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS.PLANTA MEDICA,78(8),800-806.
MLA He Fan,et al."Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS".PLANTA MEDICA 78.8(2012):800-806.
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