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题名: Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography
作者: Li, Yun1;  Lee, Milton L.2;  Jin, Jing1;  Chen, Jiping1
关键词: Polymeric monoliths ;  Poly(ethylene glycol) methacrylate ;  Normal phase liquid chromatography ;  Hydrophilic ;  Dual retention capability
刊名: TALANTA
发表日期: 2012-09-15
DOI: 10.1016/j.talanta.2012.04.066
卷: 99, 页:91-98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A novel porous poly(ethylene glycol) methacrylate-based monolithic column for normal phase liquid chromatography was prepared by thermally initiated polymerization of poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EDMA) in the presence of selected porogens. The monolith was macroscopically homogeneous, had low flow resistance, and did not swell or shrink significantly in solvents of different polarities. Inverse size-exclusion data indicate that the monolith had a total porosity of 79.2%, including an external porosity of 69.3% and an internal porosity of 9.9%. Due to its mild polarity (hydrophilicity), the PEG-functionalized monolith could perform traditional normal phase chromatography using non-polar solvents The van Deemter plot demonstrated that the column efficiency of 33,600-34,320 theoretical plates/m could be achieved at a linear flow velocity of 0.9-1.5 mm/s. The dual retention capability (both weak hydrophilic and hydrophobic interactions) investigated in this paper explains well why the PEG-functionalized monolith could operate in various chromatographic modes. (C) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: CAPILLARY ELECTROCHROMATOGRAPHY ;  POLYMER MONOLITHS ;  MASS-SPECTROMETRY ;  STATIONARY PHASES ;  SEPARATION MEDIA ;  SILICA COLUMNS ;  HPLC ;  PEPTIDES ;  ACIDS ;  RODS
语种: 英语
WOS记录号: WOS:000309785300013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142969
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Liaoning, Peoples R China
2.Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

Recommended Citation:
Li, Yun,Lee, Milton L.,Jin, Jing,et al. Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography[J]. TALANTA,2012,99:91-98.
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