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题名: Amino Acid Ionic Liquid Modified Mesoporous Carbon: A Tailor-made Nanostructure Biosensing Platform
作者: Wu, Lidong1;  Lu, Xianbo1;  Zhang, Haijun1;  Chen, Jiping1
关键词: biosensors ;  carbon materials ;  enzymes ;  room temperature ionic liquids (RTILs) ;  phenol
刊名: CHEMSUSCHEM
发表日期: 2012
DOI: 10.1002/cssc.201200274
卷: 5, 期:10, 页:1918-1925
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A novel nanocomposite based on ordered graphitized mesoporous carbon (GMC) and amino acid ionic liquids (AAIL) is obtained through controlled surface modification of GMC with hydrophilic AAILs (1-ethyl-3-methylimidazolium alanine, EMIM[Ala]), which is used as a platform for a tyrosinase biosensor to detect phenol. The GMCAAIL nanocomposite possesses a better biocompatibility and improved aqueous-phase dispersion than hydrophobic GMC alone, owing to the introduction of hydrophilic and biocompatible AAILs. Comparative studies revealed that the catalytic activity of tyrosinase for phenol in phosphate buffer solution (PBS) containing EMIM[Ala] was about ten times higher than that in pure PBS. By entrapping tyrosinase molecules into the mesopores of GMC, making use of the synergy effect of GMC and AAIL (the interspace confinement effect, the anti-fouling ability, and the biocompatible microenvironment), the GMCAAIL-based biosensors display superior analytical performance to GMC-based ones in terms of signal-to-noise ratio, stability, repeatability, and working life. After 21-day storage, the electrode retained more than 90% of its initial response, indicating that surface modification of GMC with hydrophilic and biocompatible AAILs could significantly prolong the life of tyrosinase in vitro. The GMC10EMIM[Ala]-based biosensor demonstrates a linear response for phenol concentrations from 0.1 to 10 mu mol?L-1 with a low detection limit of 20 nmol?L-1 and sensitivity of 1385 mA?cm-2?M-1. The GMCAAIL nanocomposite proves to be a promising platform for enzyme-based biosensors and biocatalysis.
关键词[WOS]: PHYSICOCHEMICAL PROPERTIES ;  FABRICATION ;  ELECTRODES ;  TYROSINASE ;  CATALYSIS ;  PHENOL
语种: 英语
WOS记录号: WOS:000310074200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143004
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Lidong,Lu, Xianbo,Zhang, Haijun,et al. Amino Acid Ionic Liquid Modified Mesoporous Carbon: A Tailor-made Nanostructure Biosensing Platform[J]. CHEMSUSCHEM,2012,5(10):1918-1925.
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