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Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry
Zhou, Lina1; Ding, Lili2; Yin, Peiyuan1; Lu, Xin1; Wang, Xiaomei2; Niu, Junqi2; Gao, Pujun2; Xu, Guowang1
KeywordMetabolic Profiling Hepatocellular Carcinoma Hepatitis b Hepatitis c Liver Cirrhosis Arachidonic Acid Lysophosphatidylcholine
Source PublicationJOURNAL OF PROTEOME RESEARCH
2012-11-01
DOI10.1021/pr300683a
Volume11Issue:11Pages:5433-5442
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordT-CELL PROLIFERATION ; INDOLEAMINE 2,3-DIOXYGENASE ; TRYPTOPHAN DEGRADATION ; LIVER-CIRRHOSIS ; ALPHA-FETOPROTEIN ; LYSOPHOSPHATIDYLCHOLINE ; CANCER ; BIOMARKERS ; PLASMA ; INFLAMMATION
AbstractThe objective of the present study was to explore the common and specific metabolic alterations of hepatocellular carcinoma (HCC) infected with hepatitis B virus (HBV) or hepatitis C virus (HCV). Serum profiling data revealed that the two HCC groups shared a mainly similar metabolic profile, providing a basis for investigating their common tumor pathogenesis mechanism and early diagnosis biomarkers. Arachidonic acid as a pro-inflammatory precursor increased significantly in the HCC group compared to the cirrhosis and healthy control. And the lysophosphatidylcholines (lysoPCs) with polyunsaturated fatty acid acyl chain with potent anti-inflammatory activity significantly decreased in the HCC and cirrhosis groups compared to those in the healthy control group, which may partly contribute to maintaining chronic inflammation and benefit the initiation and progression of the malignant hepatic tumor. The decreased ratios of polyunsaturated lysoPCs to saturated lysoPCs in HCC groups compared to chronic liver diseases infected with HBV or HCV and healthy control further demonstrated that a malignant liver tumor exerts profound influences independent of virus infection. Especially, serum endocannabinoids anandamide (AEA) and palmitylethanolamide (PEA) were found significantly elevated in HCC groups compared to healthy control, and in HCC with HCV compared to corresponding chronic liver diseases. AEA, PEA, or their combination showed better sensitivity, specificity, and the area under the curve for distinguishing HCC from chronic liver diseases, showing they are potential biomarkers to distinguish the HCC from cirrhosis infected with HCV.
Language英语
WOS IDWOS:000311190600027
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Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143005
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Jilin Univ, Hosp 1, Dept Hepatol, Changchun 130021, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Lina,Ding, Lili,Yin, Peiyuan,et al. Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(11):5433-5442.
APA Zhou, Lina.,Ding, Lili.,Yin, Peiyuan.,Lu, Xin.,Wang, Xiaomei.,...&Xu, Guowang.(2012).Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,11(11),5433-5442.
MLA Zhou, Lina,et al."Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 11.11(2012):5433-5442.
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