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Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry
Zhou, Lina1; Ding, Lili2; Yin, Peiyuan1; Lu, Xin1; Wang, Xiaomei2; Niu, Junqi2; Gao, Pujun2; Xu, Guowang1
关键词Metabolic Profiling Hepatocellular Carcinoma Hepatitis b Hepatitis c Liver Cirrhosis Arachidonic Acid Lysophosphatidylcholine
刊名JOURNAL OF PROTEOME RESEARCH
2012-11-01
DOI10.1021/pr300683a
11期:11页:5433-5442
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]T-CELL PROLIFERATION ; INDOLEAMINE 2,3-DIOXYGENASE ; TRYPTOPHAN DEGRADATION ; LIVER-CIRRHOSIS ; ALPHA-FETOPROTEIN ; LYSOPHOSPHATIDYLCHOLINE ; CANCER ; BIOMARKERS ; PLASMA ; INFLAMMATION
英文摘要The objective of the present study was to explore the common and specific metabolic alterations of hepatocellular carcinoma (HCC) infected with hepatitis B virus (HBV) or hepatitis C virus (HCV). Serum profiling data revealed that the two HCC groups shared a mainly similar metabolic profile, providing a basis for investigating their common tumor pathogenesis mechanism and early diagnosis biomarkers. Arachidonic acid as a pro-inflammatory precursor increased significantly in the HCC group compared to the cirrhosis and healthy control. And the lysophosphatidylcholines (lysoPCs) with polyunsaturated fatty acid acyl chain with potent anti-inflammatory activity significantly decreased in the HCC and cirrhosis groups compared to those in the healthy control group, which may partly contribute to maintaining chronic inflammation and benefit the initiation and progression of the malignant hepatic tumor. The decreased ratios of polyunsaturated lysoPCs to saturated lysoPCs in HCC groups compared to chronic liver diseases infected with HBV or HCV and healthy control further demonstrated that a malignant liver tumor exerts profound influences independent of virus infection. Especially, serum endocannabinoids anandamide (AEA) and palmitylethanolamide (PEA) were found significantly elevated in HCC groups compared to healthy control, and in HCC with HCV compared to corresponding chronic liver diseases. AEA, PEA, or their combination showed better sensitivity, specificity, and the area under the curve for distinguishing HCC from chronic liver diseases, showing they are potential biomarkers to distinguish the HCC from cirrhosis infected with HCV.
语种英语
WOS记录号WOS:000311190600027
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143005
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Jilin Univ, Hosp 1, Dept Hepatol, Changchun 130021, Peoples R China
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Zhou, Lina,Ding, Lili,Yin, Peiyuan,et al. Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(11):5433-5442.
APA Zhou, Lina.,Ding, Lili.,Yin, Peiyuan.,Lu, Xin.,Wang, Xiaomei.,...&Xu, Guowang.(2012).Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,11(11),5433-5442.
MLA Zhou, Lina,et al."Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 11.11(2012):5433-5442.
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