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题名: Insights into the regulation of human CNV-miRNAs from the view of their target genes
作者: Wu, Xudong1;  Zhang, Dinglin1;  Li, Guohui1
关键词: Copy number variation ;  miRNA ;  Expression variation ;  HapMap ethnic population
刊名: BMC GENOMICS
发表日期: 2012-12-18
DOI: 10.1186/1471-2164-13-707
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology ;  Genetics & Heredity
研究领域[WOS]: Biotechnology & Applied Microbiology ;  Genetics & Heredity
英文摘要: Background: microRNAs (miRNAs) represent a class of small (typically 22 nucleotides in length) non-coding RNAs that can degrade their target mRNAs or block their translation. Recent research showed that copy number alterations of miRNAs and their target genes are highly prevalent in cancers; however, the evolutionary and biological functions of naturally existing copy number variable miRNAs (CNV-miRNAs) among individuals have not been studied extensively throughout the genome.
关键词[WOS]: COPY-NUMBER VARIATION ;  HUMAN GENOME ;  MICROARRAY ANALYSIS ;  MICRORNA TARGETS ;  EXPRESSION ;  REVEALS ;  DROSOPHILA ;  SELECTION ;  DOSAGE ;  MOUSE
语种: 英语
WOS记录号: WOS:000315327300001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143046
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Xudong,Zhang, Dinglin,Li, Guohui. Insights into the regulation of human CNV-miRNAs from the view of their target genes[J]. BMC GENOMICS,2012,13.
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