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题名: A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
作者: Li, Xiuxiu1;  Xu, Xue1;  Wang, Jinan1;  Yu, Hua1;  Wang, Xia1;  Yang, Hongjun2;  Xu, Haiyu2;  Tang, Shihuan2;  Li, Yan3;  Yang, Ling4;  Huang, Luqi2;  Wang, Yonghua1;  Yang, Shengli4
刊名: PLOS ONE
发表日期: 2012-09-04
DOI: 10.1371/journal.pone.0043918
卷: 7, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.
关键词[WOS]: SALVIANOLIC-ACID-B ;  VEIN ENDOTHELIAL-CELLS ;  SMOOTH-MUSCLE-CELLS ;  P-GLYCOPROTEIN ;  GINSENG SAPONINS ;  DRUG DISCOVERY ;  IN-VITRO ;  ORAL BIOAVAILABILITY ;  NETWORK PHARMACOLOGY ;  MOLECULAR-MECHANICS
语种: 英语
WOS记录号: WOS:000308577600021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143049
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.NW A&F Univ, Bioinformat Ctr, Coll Life Sci, Yangling, Shaanxi, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
3.Dalian Univ Technol, Sch Chem Engn, Dalian, Liaoning, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Liaoning, Peoples R China

Recommended Citation:
Li, Xiuxiu,Xu, Xue,Wang, Jinan,et al. A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment[J]. PLOS ONE,2012,7(9).
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