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A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
Li, Xiuxiu1; Xu, Xue1; Wang, Jinan1; Yu, Hua1; Wang, Xia1; Yang, Hongjun2; Xu, Haiyu2; Tang, Shihuan2; Li, Yan3; Yang, Ling4; Huang, Luqi2; Wang, Yonghua1; Yang, Shengli4
刊名PLOS ONE
2012-09-04
DOI10.1371/journal.pone.0043918
7期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SALVIANOLIC-ACID-B ; VEIN ENDOTHELIAL-CELLS ; SMOOTH-MUSCLE-CELLS ; P-GLYCOPROTEIN ; GINSENG SAPONINS ; DRUG DISCOVERY ; IN-VITRO ; ORAL BIOAVAILABILITY ; NETWORK PHARMACOLOGY ; MOLECULAR-MECHANICS
英文摘要Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.
语种英语
WOS记录号WOS:000308577600021
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143049
专题中国科学院大连化学物理研究所
作者单位1.NW A&F Univ, Bioinformat Ctr, Coll Life Sci, Yangling, Shaanxi, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
3.Dalian Univ Technol, Sch Chem Engn, Dalian, Liaoning, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Liaoning, Peoples R China
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GB/T 7714
Li, Xiuxiu,Xu, Xue,Wang, Jinan,et al. A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment[J]. PLOS ONE,2012,7(9).
APA Li, Xiuxiu.,Xu, Xue.,Wang, Jinan.,Yu, Hua.,Wang, Xia.,...&Yang, Shengli.(2012).A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment.PLOS ONE,7(9).
MLA Li, Xiuxiu,et al."A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment".PLOS ONE 7.9(2012).
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