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A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
Li, Xiuxiu1; Xu, Xue1; Wang, Jinan1; Yu, Hua1; Wang, Xia1; Yang, Hongjun2; Xu, Haiyu2; Tang, Shihuan2; Li, Yan3; Yang, Ling4; Huang, Luqi2; Wang, Yonghua1; Yang, Shengli4
Source PublicationPLOS ONE
2012-09-04
DOI10.1371/journal.pone.0043918
Volume7Issue:9
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordSALVIANOLIC-ACID-B ; VEIN ENDOTHELIAL-CELLS ; SMOOTH-MUSCLE-CELLS ; P-GLYCOPROTEIN ; GINSENG SAPONINS ; DRUG DISCOVERY ; IN-VITRO ; ORAL BIOAVAILABILITY ; NETWORK PHARMACOLOGY ; MOLECULAR-MECHANICS
AbstractCompound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.
Language英语
WOS IDWOS:000308577600021
Citation statistics
Cited Times:89[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143049
Collection中国科学院大连化学物理研究所
Affiliation1.NW A&F Univ, Bioinformat Ctr, Coll Life Sci, Yangling, Shaanxi, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
3.Dalian Univ Technol, Sch Chem Engn, Dalian, Liaoning, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiuxiu,Xu, Xue,Wang, Jinan,et al. A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment[J]. PLOS ONE,2012,7(9).
APA Li, Xiuxiu.,Xu, Xue.,Wang, Jinan.,Yu, Hua.,Wang, Xia.,...&Yang, Shengli.(2012).A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment.PLOS ONE,7(9).
MLA Li, Xiuxiu,et al."A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment".PLOS ONE 7.9(2012).
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