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题名: Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples
作者: Jian, Guiqin1, 2;  Liu, Yuxing1, 2;  He, Xiwen1, 2;  Chen, Langxing1, 2;  Zhang, Yukui1, 2, 3
刊名: NANOSCALE
发表日期: 2012
DOI: 10.1039/c2nr31430d
卷: 4, 期:20, 页:6336-6342
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: In this study, we report a novel method to synthesize core-shell structured Fe3O4 nanoparticles (NPs) covalently functionalized with iminodiacetic acid (IDA) via click chemistry between the azide and alkyne groups and charged with Cu2+. Firstly, the Fe3O4@SiO2 NPs were obtained using tetraethoxysilane (TEOS) to form a silica shell on the surface of the Fe3O4 core. The azide group-modified Fe3O4@SiO2 NPs were obtained by a sol-gel process using 3-azidopropyltriethoxysilane (AzPTES) as the silane agent. Fe3O4@SiO2-N-3 was directly reacted with N-propargyl iminodiacetic via click chemistry, in the presence of a Cu(I) catalyst, to acquire the IDA-modified Fe3O4 NPs. Finally, through the addition of Cu2+, the Fe3O4@SiO2 IDA-Cu NP product was obtained. The morphology, structure and composition of the NPs were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The resulting NPs showed a strong magnetic response to an externally applied magnetic field, a high adsorption capacity and excellent specificity towards hemoglobin (Hb). In addition, the Fe3O4@SiO2-IDA-Cu NPs can be used for the selective removal of abundant Hb protein in bovine and human blood samples.
关键词[WOS]: HISTIDINE-TAGGED PROTEINS ;  MODIFIED MAGNETIC NANOPARTICLES ;  AFFINITY-CHROMATOGRAPHY ;  CORE/SHELL NANOPARTICLES ;  SEPARATION ;  MICROSPHERES ;  SURFACES ;  TRIAZOLE ;  AZIDE ;  SHELL
语种: 英语
WOS记录号: WOS:000310976800026
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143052
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Jian, Guiqin,Liu, Yuxing,He, Xiwen,et al. Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples[J]. NANOSCALE,2012,4(20):6336-6342.
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