DICP OpenIR
Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography
Yu, Hui1; Yin, Chenghua1; Jia, Cunyu1; Jin, Yu1; Ke, Yanxiong1; Liang, Xinmiao2
关键词Chiral Stationary Phases Click Chemistry Binaphthyl P-p Interaction Thermodynamic Parameters
刊名CHIRALITY
2012-05-01
DOI10.1002/chir.22039
24期:5页:391-399
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]SILICA-GEL ; EFFICIENT RESOLUTION ; ACID-DERIVATIVES ; ENANTIOSEPARATION ; SEPARATION ; ENANTIOMERS ; RECOGNITION ; TEMPERATURE ; MECHANISM ; BINOL
英文摘要Two click binaphthyl chiral stationary phases were synthesized and evaluated by liquid chromatography. Their structures incorporate S-(-)-1,1'-binaphthyl moiety as the chiral selector and 1,2,3-triazole ring as the spacer. These chiral stationary phases (CSPs) allowed the efficient resolution for a wide range of racemic BINOL derivatives, particularly for nonpolar diether derivatives and 3-phenyl indolin-2-one analogs. The chromatographic data showed that the pp interaction was crucial for enantiorecognition of these CSPs. Loss of enantioselectivity observed on CSP3, which are lacking the triazole ring linkage, indicated that the triazole ring linkage took part in the enantioseparation process, although it was remote from the chiral selector of the CSP. The substitution of the phenyl group at 6 and 6' positions can significantly improve the separation ability of the CSP. The chiral recognition mechanism was also investigated by tracking the elution orders and studying the thermodynamic parameters. Chirality 24:391399, 2012. Copyright (c) 2012 Wiley Periodicals, Inc.
语种英语
WOS记录号WOS:000303237200006
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143073
专题中国科学院大连化学物理研究所
作者单位1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Yu, Hui,Yin, Chenghua,Jia, Cunyu,et al. Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography[J]. CHIRALITY,2012,24(5):391-399.
APA Yu, Hui,Yin, Chenghua,Jia, Cunyu,Jin, Yu,Ke, Yanxiong,&Liang, Xinmiao.(2012).Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography.CHIRALITY,24(5),391-399.
MLA Yu, Hui,et al."Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography".CHIRALITY 24.5(2012):391-399.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Hui]的文章
[Yin, Chenghua]的文章
[Jia, Cunyu]的文章
百度学术
百度学术中相似的文章
[Yu, Hui]的文章
[Yin, Chenghua]的文章
[Jia, Cunyu]的文章
必应学术
必应学术中相似的文章
[Yu, Hui]的文章
[Yin, Chenghua]的文章
[Jia, Cunyu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。