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题名: Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities
作者: Hou Shuhua1, 2;  Liu Wujun1;  Zhao Zongbao1
关键词: NAD analog ;  pyrophosphate ;  bioactivity ;  alcohol dehydrogenase
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2012-02-01
DOI: 10.6023/cjoc1106032
卷: 32, 期:2, 页:349-353
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: Four methods were tested to synthesize nicotinamide adenine dinucleotide (NAD) analogs, and 5 NAD analogs were prepared. Assays of these NAD analogs indicated that malic enzyme and alcohol dehydrogenase had about 13%similar to 30% enzymatic activity in the presence of analog 3b or 3d, whereas significantly lower activities were observed in the presence of analog 3a, 3c or 3e.
关键词[WOS]: CHEMICAL-SYNTHESIS ;  DEHYDROGENASE ;  NUCLEOTIDE ;  PHOSPHATE ;  ACID
语种: 英语
WOS记录号: WOS:000301616200014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143151
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Hou Shuhua,Liu Wujun,Zhao Zongbao. Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):349-353.
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