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Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities
Hou Shuhua1,2; Liu Wujun1; Zhao Zongbao1
KeywordNad Analog Pyrophosphate Bioactivity Alcohol Dehydrogenase
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
2012-02-01
DOI10.6023/cjoc1106032
Volume32Issue:2Pages:349-353
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordCHEMICAL-SYNTHESIS ; DEHYDROGENASE ; NUCLEOTIDE ; PHOSPHATE ; ACID
AbstractFour methods were tested to synthesize nicotinamide adenine dinucleotide (NAD) analogs, and 5 NAD analogs were prepared. Assays of these NAD analogs indicated that malic enzyme and alcohol dehydrogenase had about 13%similar to 30% enzymatic activity in the presence of analog 3b or 3d, whereas significantly lower activities were observed in the presence of analog 3a, 3c or 3e.
Language英语
WOS IDWOS:000301616200014
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143151
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Hou Shuhua,Liu Wujun,Zhao Zongbao. Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):349-353.
APA Hou Shuhua,Liu Wujun,&Zhao Zongbao.(2012).Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(2),349-353.
MLA Hou Shuhua,et al."Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.2(2012):349-353.
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