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题名: Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry
作者: Chen, Shili1;  Wei, Cong2;  Gao, Peng1;  Kong, Hongwei1;  Jia, Zhenhua2;  Hu, Chunxiu1;  Dai, Weidong1;  Wu, Yiling2;  Xu, Guowang1
关键词: Depression ;  Allium macrostemon ;  Lipidomics ;  Acylcarnitine ;  Liquid chromatography-mass spectrometry
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2014-02-15
DOI: 10.1016/j.jpba.2013.10.045
卷: 89, 页:122-129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: The present study aimed to investigate the anti-depressive effect of the traditional Chinese medicine Allium macrostemon in a rat model of depression induced by exposure to chronic immobilization stress. Lipid and acylcamitine metabolism were set into the focus of this study due to their key role in the pathogenesis of depression. Plasma lipid profiling was performed by ultra fast liquid chromatography/ion trap-time of flight mass spectrometry. Ultra-high performance liquid chromatography/triple quadrupole mass spectrometry was used to characterize the plasma acylcarnitine profile. Principal component analysis (PCA) revealed distinct differences in plasma lipid and acylcarnitine profiles of depressed rats from those in the control rats, which were also validated by univariate analysis. Several lysophosphatidylcholines (LPC LPC (20:1), LPC (O-16:2), and LPC (O-18:3)) as well as most medium- and long-chain acylcarnitines were elevated, while some phosphatidylcholines (PC (32:1), PC (36:4 ->:5), PC (37:4), PC (38:4 ->:6), PC (40:6), PC (O-36:4), and PC (O-38:5)) and triglycerides (TG (58:12), TG (60:12), and TG (62:13 ->:14)) were decreased in the plasma of depressed rats. These changes indicate that depressed rats were associated with inflammatory conditions and an incomplete beta-oxidation of fatty acids. Most of these dysregulated metabolites were returned to their normal levels after treatment with A. macrostemon according to PCA and univariate analysis, highlighting the anti-depressive effect of this traditional Chinese medicine. These results show that liquid chromatography/mass spectrometrybased quantitative metabolic profiling method is a useful tool to investigate the metabolic changes in depression and the anti-depressive effect of traditional Chinese medicine. (C) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: TO-MODERATE DEPRESSION ;  ACID BETA-OXIDATION ;  MASS-SPECTROMETRY ;  ENDOTHELIAL-CELLS ;  RESTRAINT STRESS ;  CULTURED HUMAN ;  LYSOPHOSPHATIDYLCHOLINE ;  METABOLOME ;  EXPRESSION ;  CARNITINE
语种: 英语
WOS记录号: WOS:000330487000019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143168
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Peoples R China

Recommended Citation:
Chen, Shili,Wei, Cong,Gao, Peng,et al. Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2014,89:122-129.
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