中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation
作者: Xu, Guiju1, 2;  Liu, Shengju1, 2;  Niu, Huan1, 2;  Lv, Wenping1;  Wu, Ren'an1
刊名: RSC ADVANCES
发表日期: 2014
DOI: 10.1039/c4ra03993a
卷: 4, 期:64, 页:33986-33997
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Chemo-photothermal therapy with the combination of chemotherapy and photothermal therapy has emerged as a promising anticancer treatment for its synergistic effects. In this work, the functionalized mesoporous carbon nanoparticles (FA/PEI/O-MCN) were constructed by modifying the mesoporous carbon nanoparticles (MCN) with polyethylenimine (PEI) and folic acid (FA) for the targeted chemophotothermal therapy. The FA/PEI/O-MCN exhibited strong light absorption and high photothermal conversion efficiency in the near-infrared (NIR) region due to the graphitic structure of MCN. Meanwhile, FA/PEI/O-MCN displayed high drug loading capacity using doxorubicin hydrochloride (DOX) as a model drug. Flow cytometry analysis and competitive binding experiments verified that the FA modification could significantly enhance the uptake of FA/PEI/O-MCN by HeLa cells with folate receptors (FR) over-expressing. Comparing with chemotherapy or photothermal therapy alone, the DOX-loaded FA/PEI/OMCN demonstrated the synergistic effects and resulted in the higher therapeutic efficacy. We believe that the FA/PEI/O-MCN could be applied as an efficient chemo-photothermal platform to realize the targeted synergistic therapy.
关键词[WOS]: COATED GOLD NANORODS ;  REDUCED GRAPHENE OXIDE ;  DRUG-DELIVERY SYSTEM ;  SILICA NANOPARTICLES ;  OPTICAL-PROPERTIES ;  CONTROLLED-RELEASE ;  NANOTUBES ;  LIGHT ;  NANOSPHERES ;  DOXORUBICIN
语种: 英语
WOS记录号: WOS:000341287300042
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143169
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Xu, Guiju,Liu, Shengju,Niu, Huan,et al. Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation[J]. RSC ADVANCES,2014,4(64):33986-33997.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Xu, Guiju]'s Articles
 [Liu, Shengju]'s Articles
 [Niu, Huan]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Xu, Guiju]‘s Articles
 [Liu, Shengju]‘s Articles
 [Niu, Huan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace