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Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation
Xu, Guiju1,2; Liu, Shengju1,2; Niu, Huan1,2; Lv, Wenping1; Wu, Ren'an1
刊名RSC ADVANCES
2014
DOI10.1039/c4ra03993a
4期:64页:33986-33997
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]COATED GOLD NANORODS ; REDUCED GRAPHENE OXIDE ; DRUG-DELIVERY SYSTEM ; SILICA NANOPARTICLES ; OPTICAL-PROPERTIES ; CONTROLLED-RELEASE ; NANOTUBES ; LIGHT ; NANOSPHERES ; DOXORUBICIN
英文摘要Chemo-photothermal therapy with the combination of chemotherapy and photothermal therapy has emerged as a promising anticancer treatment for its synergistic effects. In this work, the functionalized mesoporous carbon nanoparticles (FA/PEI/O-MCN) were constructed by modifying the mesoporous carbon nanoparticles (MCN) with polyethylenimine (PEI) and folic acid (FA) for the targeted chemophotothermal therapy. The FA/PEI/O-MCN exhibited strong light absorption and high photothermal conversion efficiency in the near-infrared (NIR) region due to the graphitic structure of MCN. Meanwhile, FA/PEI/O-MCN displayed high drug loading capacity using doxorubicin hydrochloride (DOX) as a model drug. Flow cytometry analysis and competitive binding experiments verified that the FA modification could significantly enhance the uptake of FA/PEI/O-MCN by HeLa cells with folate receptors (FR) over-expressing. Comparing with chemotherapy or photothermal therapy alone, the DOX-loaded FA/PEI/OMCN demonstrated the synergistic effects and resulted in the higher therapeutic efficacy. We believe that the FA/PEI/O-MCN could be applied as an efficient chemo-photothermal platform to realize the targeted synergistic therapy.
语种英语
WOS记录号WOS:000341287300042
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143169
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Xu, Guiju,Liu, Shengju,Niu, Huan,et al. Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation[J]. RSC ADVANCES,2014,4(64):33986-33997.
APA Xu, Guiju,Liu, Shengju,Niu, Huan,Lv, Wenping,&Wu, Ren'an.(2014).Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation.RSC ADVANCES,4(64),33986-33997.
MLA Xu, Guiju,et al."Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation".RSC ADVANCES 4.64(2014):33986-33997.
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