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Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta
Zhang, Hong1; Zhang, Dan-Dan3; Lao, Yuan-Zhi1; Fu, Wen-Wei1; Liang, Shuang1; Yuan, Qing-Hong4; Yang, Ling5; Xu, Hong-Xi1,2
Source PublicationJOURNAL OF NATURAL PRODUCTS
2014-07-01
DOI10.1021/np5003498
Volume77Issue:7Pages:1700-1707
Indexed BySCI ; IC
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordBIOASSAY-GUIDED ISOLATION ; COLON-CANCER CELLS ; GAMMA-MANGOSTIN ; POLYPRENYLATED XANTHONES ; BENZOPHENONE DERIVATIVES ; ABSOLUTE-CONFIGURATION ; NATURAL-PRODUCTS ; OBLONGIFOLIA ; LEAVES ; FRUITS
AbstractFive new prenylated benzoylphloroglucinol derivatives, garciesculentones A-E (1-5), a new xanthone, garciesculenxanthone A (6), and 15 known compounds were isolated from the petroleum ether extract and the EtOAc-soluble fraction of a 80% (v/v) EtOH extract of Garcinia esculenta. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD and a convenient modified Mosher's method were used to determine the absolute configurations. The cytotoxicity of these compounds were evaluated by MTT assay against three human cancer cell lines (HepG2, MCF-7, and MDA-MB-231) and against normal hepatic cells (HL-7702). In addition, these isolates were evaluated for their inhibitory effects on interferon-gamma plus lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
Language英语
WOS IDWOS:000339604300021
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143171
Collection中国科学院大连化学物理研究所
Affiliation1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China
4.E China Normal Univ, Dept Phys, Shanghai 200241, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Hong,Zhang, Dan-Dan,Lao, Yuan-Zhi,et al. Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(7):1700-1707.
APA Zhang, Hong.,Zhang, Dan-Dan.,Lao, Yuan-Zhi.,Fu, Wen-Wei.,Liang, Shuang.,...&Xu, Hong-Xi.(2014).Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta.JOURNAL OF NATURAL PRODUCTS,77(7),1700-1707.
MLA Zhang, Hong,et al."Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta".JOURNAL OF NATURAL PRODUCTS 77.7(2014):1700-1707.
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