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题名: Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta
作者: Zhang, Hong1;  Zhang, Dan-Dan3;  Lao, Yuan-Zhi1;  Fu, Wen-Wei1;  Liang, Shuang1;  Yuan, Qing-Hong4;  Yang, Ling5;  Xu, Hong-Xi1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014-07-01
DOI: 10.1021/np5003498
卷: 77, 期:7, 页:1700-1707
收录类别: SCI ;  IC
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Five new prenylated benzoylphloroglucinol derivatives, garciesculentones A-E (1-5), a new xanthone, garciesculenxanthone A (6), and 15 known compounds were isolated from the petroleum ether extract and the EtOAc-soluble fraction of a 80% (v/v) EtOH extract of Garcinia esculenta. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD and a convenient modified Mosher's method were used to determine the absolute configurations. The cytotoxicity of these compounds were evaluated by MTT assay against three human cancer cell lines (HepG2, MCF-7, and MDA-MB-231) and against normal hepatic cells (HL-7702). In addition, these isolates were evaluated for their inhibitory effects on interferon-gamma plus lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
关键词[WOS]: BIOASSAY-GUIDED ISOLATION ;  COLON-CANCER CELLS ;  GAMMA-MANGOSTIN ;  POLYPRENYLATED XANTHONES ;  BENZOPHENONE DERIVATIVES ;  ABSOLUTE-CONFIGURATION ;  NATURAL-PRODUCTS ;  OBLONGIFOLIA ;  LEAVES ;  FRUITS
语种: 英语
WOS记录号: WOS:000339604300021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143171
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China
4.E China Normal Univ, Dept Phys, Shanghai 200241, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, Hong,Zhang, Dan-Dan,Lao, Yuan-Zhi,et al. Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(7):1700-1707.
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