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题名: Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand
作者: Zhu, Fu-Lin1, 2;  Zou, Yuan1;  Zhang, De-Yang1, 2;  Wang, Ya-Hui1;  Hu, Xin-Hu1;  Chen, Song1;  Xu, Jie1;  Hu, Xiang-Ping1
关键词: alkylation ;  asymmetric catalysis ;  copper ;  ligand design ;  synthetic methods
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
发表日期: 2014-01-27
DOI: 10.1002/anie.201309182
卷: 53, 期:5, 页:1410-1414
收录类别: SCI ;  IC ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The first enantioselective copper-catalyzed decarboxylative propargylic alkylation has been developed. Treatment of propargyl beta-ketoesters with a catalyst, prepared in situ from [Cu(CH3CN)(4)BF4] and a newly developed chiral tridentate ketimine P,N,N-ligand under mild reaction conditions, generates beta-ethynyl ketones in good yields and with high enantioselectivities without requiring the pregeneration of ketone enolates. This new process provides facile access to a range of chiral beta-ethynyl ketones in a highly enantioenriched form.
关键词[WOS]: SUBSTITUTION-REACTIONS ;  CONJUGATE ADDITION ;  TERMINAL ALKYNES ;  KETO-ESTERS ;  AMINATION ;  AMINES ;  HYDROGENOLYSIS ;  COMPLEXES ;  ACETATES ;  SCOPE
语种: 英语
WOS记录号: WOS:000336504500041
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143181
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhu, Fu-Lin,Zou, Yuan,Zhang, De-Yang,et al. Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(5):1410-1414.
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