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题名: Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases
作者: Ai, Limei1;  Zhu, Liangliang2;  Yang, Lu3;  Ge, Guangbo4, 5;  Cao, Yunfeng4, 5;  Liu, Yong4, 5;  Fang, Zhongze4, 5;  Zhang, Yanyan4, 5
关键词: Niloinib ;  the selective inhibitor ;  UDP-glucuronosyltransferase 1A1
刊名: XENOBIOTICA
发表日期: 2014-04-01
DOI: 10.3109/00498254.2013.840750
卷: 44, 期:4, 页:320-325
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Nilotinib, a tyrosine kinase inhibitor, could potently inhibit SN-38 glucuronidation mainly catalyzed by UDP-glucuronosyltransferase (UGT) 1A1. This study was designed to investigate whether nilotinib can be used as a selective inhibitor of UGT1A1 in human liver.
关键词[WOS]: TYROSINE KINASE INHIBITORS ;  DRUG-GLUCURONIDATION ;  PHENYLBUTAZONE ;  POLYMORPHISM ;  PREDICTION ;  SUBSTRATE ;  KINETICS ;  ISOFORM ;  PROBES
语种: 英语
WOS记录号: WOS:000332738200003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143206
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Med Univ, Affiliated Hosp 1, Dept Hematol, Jinzhou 121001, Peoples R China
2.Anqing Normal Univ, Sch Life Sci, Dept Quarantine Anim & Plants, Anqing, Peoples R China
3.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dept Anal Chinese Med, Dalian, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian, Peoples R China
5.Liaoning Med Univ, Affiliated Hosp 1, Dalian, Peoples R China

Recommended Citation:
Ai, Limei,Zhu, Liangliang,Yang, Lu,et al. Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases[J]. XENOBIOTICA,2014,44(4):320-325.
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