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Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases
Ai, Limei1; Zhu, Liangliang2; Yang, Lu3; Ge, Guangbo4,5; Cao, Yunfeng4,5; Liu, Yong4,5; Fang, Zhongze4,5; Zhang, Yanyan4,5
KeywordNiloinib The Selective Inhibitor Udp-glucuronosyltransferase 1a1
Source PublicationXENOBIOTICA
2014-04-01
DOI10.3109/00498254.2013.840750
Volume44Issue:4Pages:320-325
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS KeywordTYROSINE KINASE INHIBITORS ; DRUG-GLUCURONIDATION ; PHENYLBUTAZONE ; POLYMORPHISM ; PREDICTION ; SUBSTRATE ; KINETICS ; ISOFORM ; PROBES
Abstract1. Nilotinib, a tyrosine kinase inhibitor, could potently inhibit SN-38 glucuronidation mainly catalyzed by UDP-glucuronosyltransferase (UGT) 1A1. This study was designed to investigate whether nilotinib can be used as a selective inhibitor of UGT1A1 in human liver.
Language英语
WOS IDWOS:000332738200003
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143206
Collection中国科学院大连化学物理研究所
Affiliation1.Liaoning Med Univ, Affiliated Hosp 1, Dept Hematol, Jinzhou 121001, Peoples R China
2.Anqing Normal Univ, Sch Life Sci, Dept Quarantine Anim & Plants, Anqing, Peoples R China
3.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dept Anal Chinese Med, Dalian, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian, Peoples R China
5.Liaoning Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Ai, Limei,Zhu, Liangliang,Yang, Lu,et al. Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases[J]. XENOBIOTICA,2014,44(4):320-325.
APA Ai, Limei.,Zhu, Liangliang.,Yang, Lu.,Ge, Guangbo.,Cao, Yunfeng.,...&Zhang, Yanyan.(2014).Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases.XENOBIOTICA,44(4),320-325.
MLA Ai, Limei,et al."Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases".XENOBIOTICA 44.4(2014):320-325.
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