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学科主题物理化学
Identification of Two Novel Modifications at Tryptophan Residues
Zheng, Shuzhen1; Zhang, Kai1,2,3; Tian, Shanshan2,3; He, Xiwen1; Zhang, Yukui1,4; Zhang K(张锴)
关键词Proteomics Mass Spectrometry Post-translational Modifications Tryptophan Modifications
刊名JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
2015-10-01
DOI10.1007/s13361-015-1217-8
26期:10页:1787-1790
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical ; Chemistry, Physical ; Spectroscopy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy
关键词[WOS]POSTTRANSLATIONAL MODIFICATIONS ; MASS-SPECTROMETRY ; PROTEINS ; OXIDATION ; PRODUCTS ; DAMAGE ; PTMAP ; MS
英文摘要Protein post-translational modifications (PTMs) play important roles in cellular physiology. Mass spectrometry (MS) has been developed into a powerful tool to identify all possible protein modifications. Herein, we describe our efforts to deduce the structures of two unknown modifications at tryptophan (Trp) residues (W + 92 Da and W + 108 Da). The two modifications were further confirmed by aligning the MS/MS fragmentation of synthetic peptide with in-vivo peptide identified. Finally, the mimic experiment elucidated how two Trp modifications occur. This study, therefore, expands current knowledge of Trp modifications.
语种英语
WOS记录号WOS:000361073200017
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143694
专题中国科学院大连化学物理研究所
通讯作者Zhang K(张锴)
作者单位1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Tianjin Med Univ, Dept Biochem & Mol Biol, Tianjin 300070, Peoples R China
3.Tianjin Med Univ, Tianjin Key Lab Med Epigenet, Tianjin 300070, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
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GB/T 7714
Zheng, Shuzhen,Zhang, Kai,Tian, Shanshan,et al. Identification of Two Novel Modifications at Tryptophan Residues[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2015,26(10):1787-1790.
APA Zheng, Shuzhen,Zhang, Kai,Tian, Shanshan,He, Xiwen,Zhang, Yukui,&张锴.(2015).Identification of Two Novel Modifications at Tryptophan Residues.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,26(10),1787-1790.
MLA Zheng, Shuzhen,et al."Identification of Two Novel Modifications at Tryptophan Residues".JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 26.10(2015):1787-1790.
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