DICP OpenIR
学科主题物理化学
Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells
Zhao, Tong1,2; He, Xi-Wen1,2; Li, Wen-You1,2; Zhang, Yu-Kui1,2,3; Li WY(李文友)
刊名JOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c4tb02130d
3期:11页:2388-2394
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]FLUORESCENT GOLD NANOCLUSTERS ; ONE-POT SYNTHESIS ; QUANTUM CLUSTERS ; EMISSION ; PEPTIDE ; WATER ; NANOPARTICLES ; FABRICATION ; TEMPLATES ; SENSOR
英文摘要Transferrin (Trf)-functionalized copper nanoclusters (Trf-Cu NCs) were fabricated as a novel red-emitting fluorescent probe for the targeted bioimaging of cancer cells. A one-pot approach was developed to prepare stable, water-soluble and red-emitting Trf-Cu NCs at room temperature via a biomineralization process with Trf as the template and ascorbic acid as a green reducing agent. Trf acted not only as a stabilizer and reducer, but also as a functional ligand for targeting the transferrin receptor. The asprepared Trf-Cu NCs showed an intense red fluorescence with a red emission peak at 670 nm (quantum yield about 6.2%), suggesting that the probe could potentially be used for bioimaging in vivo. The developed Trf-Cu NCs had excellent photostability and water solubility and exhibited a high specificity to transferrin receptor with negligible cytotoxicity. The probe was successfully applied to the targeted bioimaging of HeLa cells.
语种英语
WOS记录号WOS:000350983400015
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143699
专题中国科学院大连化学物理研究所
通讯作者Li WY(李文友)
作者单位1.Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
2.Nankai Univ, Res Ctr Analyt Sci, Coll Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Tong,He, Xi-Wen,Li, Wen-You,et al. Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(11):2388-2394.
APA Zhao, Tong,He, Xi-Wen,Li, Wen-You,Zhang, Yu-Kui,&李文友.(2015).Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells.JOURNAL OF MATERIALS CHEMISTRY B,3(11),2388-2394.
MLA Zhao, Tong,et al."Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells".JOURNAL OF MATERIALS CHEMISTRY B 3.11(2015):2388-2394.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2015BmKgbOdVfv.PDF(1760KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Tong]的文章
[He, Xi-Wen]的文章
[Li, Wen-You]的文章
百度学术
百度学术中相似的文章
[Zhao, Tong]的文章
[He, Xi-Wen]的文章
[Li, Wen-You]的文章
必应学术
必应学术中相似的文章
[Zhao, Tong]的文章
[He, Xi-Wen]的文章
[Li, Wen-You]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。