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学科主题: 物理化学
题名: Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells
作者: Zhao, Tong1, 2;  He, Xi-Wen1, 2;  Li, Wen-You1, 2;  Zhang, Yu-Kui1, 2, 3
通讯作者: 李文友
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c4tb02130d
卷: 3, 期:11, 页:2388-2394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Transferrin (Trf)-functionalized copper nanoclusters (Trf-Cu NCs) were fabricated as a novel red-emitting fluorescent probe for the targeted bioimaging of cancer cells. A one-pot approach was developed to prepare stable, water-soluble and red-emitting Trf-Cu NCs at room temperature via a biomineralization process with Trf as the template and ascorbic acid as a green reducing agent. Trf acted not only as a stabilizer and reducer, but also as a functional ligand for targeting the transferrin receptor. The asprepared Trf-Cu NCs showed an intense red fluorescence with a red emission peak at 670 nm (quantum yield about 6.2%), suggesting that the probe could potentially be used for bioimaging in vivo. The developed Trf-Cu NCs had excellent photostability and water solubility and exhibited a high specificity to transferrin receptor with negligible cytotoxicity. The probe was successfully applied to the targeted bioimaging of HeLa cells.
关键词[WOS]: FLUORESCENT GOLD NANOCLUSTERS ;  ONE-POT SYNTHESIS ;  QUANTUM CLUSTERS ;  EMISSION ;  PEPTIDE ;  WATER ;  NANOPARTICLES ;  FABRICATION ;  TEMPLATES ;  SENSOR
语种: 英语
WOS记录号: WOS:000350983400015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143699
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
2.Nankai Univ, Res Ctr Analyt Sci, Coll Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Zhao, Tong,He, Xi-Wen,Li, Wen-You,et al. Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(11):2388-2394.
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