DICP OpenIR
Subject Area物理化学
Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells
Zhao, Tong1,2; He, Xi-Wen1,2; Li, Wen-You1,2; Zhang, Yu-Kui1,2,3; Li WY(李文友)
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c4tb02130d
Volume3Issue:11Pages:2388-2394
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectMaterials Science, Biomaterials
WOS Research AreaMaterials Science
WOS KeywordFLUORESCENT GOLD NANOCLUSTERS ; ONE-POT SYNTHESIS ; QUANTUM CLUSTERS ; EMISSION ; PEPTIDE ; WATER ; NANOPARTICLES ; FABRICATION ; TEMPLATES ; SENSOR
AbstractTransferrin (Trf)-functionalized copper nanoclusters (Trf-Cu NCs) were fabricated as a novel red-emitting fluorescent probe for the targeted bioimaging of cancer cells. A one-pot approach was developed to prepare stable, water-soluble and red-emitting Trf-Cu NCs at room temperature via a biomineralization process with Trf as the template and ascorbic acid as a green reducing agent. Trf acted not only as a stabilizer and reducer, but also as a functional ligand for targeting the transferrin receptor. The asprepared Trf-Cu NCs showed an intense red fluorescence with a red emission peak at 670 nm (quantum yield about 6.2%), suggesting that the probe could potentially be used for bioimaging in vivo. The developed Trf-Cu NCs had excellent photostability and water solubility and exhibited a high specificity to transferrin receptor with negligible cytotoxicity. The probe was successfully applied to the targeted bioimaging of HeLa cells.
Language英语
WOS IDWOS:000350983400015
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143699
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi WY(李文友)
Affiliation1.Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
2.Nankai Univ, Res Ctr Analyt Sci, Coll Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Tong,He, Xi-Wen,Li, Wen-You,et al. Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(11):2388-2394.
APA Zhao, Tong,He, Xi-Wen,Li, Wen-You,Zhang, Yu-Kui,&李文友.(2015).Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells.JOURNAL OF MATERIALS CHEMISTRY B,3(11),2388-2394.
MLA Zhao, Tong,et al."Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells".JOURNAL OF MATERIALS CHEMISTRY B 3.11(2015):2388-2394.
Files in This Item:
File Name/Size DocType Version Access License
2015BmKgbOdVfv.PDF(1760KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, Tong]'s Articles
[He, Xi-Wen]'s Articles
[Li, Wen-You]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, Tong]'s Articles
[He, Xi-Wen]'s Articles
[Li, Wen-You]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, Tong]'s Articles
[He, Xi-Wen]'s Articles
[Li, Wen-You]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.