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学科主题: 物理化学
题名: Enhancing the performance of LC-MS for intact protein analysis by counteracting the signal suppression effects of trifluoroacetic acid during electrospray
作者: Chen, Jin1, 2;  Liu, Zheyi1, 2;  Wang, Fangjun1;  Mao, Jiawei1, 2;  Zhou, Ye1, 2;  Liu, Jing1, 2;  Zou, Hanfa1;  Zhang, Yukui1
通讯作者: FangJunWang ;  邹汉法
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2015
DOI: 10.1039/c5cc06072a
卷: 51, 期:79, 页:14758-14760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: We develop an acidic vapor assisted electrospray ionization strategy within an enclosed electrospray ionization source to counteract the ion suppression effects caused by trifluoroacetic acid. The mass spectrometry signal intensity of intact proteins was improved 10 times and the number of valid signals for E. coli intact protein samples was improved 96% by using this strategy.
关键词[WOS]: CHROMATOGRAPHY-MASS-SPECTROMETRY ;  LIQUID-CHROMATOGRAPHY ;  MOBILE-PHASE ;  IONIZATION ;  ENHANCEMENT ;  SENSITIVITY ;  SEPARATION
语种: 英语
WOS记录号: WOS:000361753000015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143704
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Chen, Jin,Liu, Zheyi,Wang, Fangjun,et al. Enhancing the performance of LC-MS for intact protein analysis by counteracting the signal suppression effects of trifluoroacetic acid during electrospray[J]. CHEMICAL COMMUNICATIONS,2015,51(79):14758-14760.
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