DICP OpenIR
学科主题物理化学
Teicoplanin bonded sub-2 mu m superficially porous particles for enantioseparation of native amino acids
Min, Yi1,2; Sui, Zhigang1; Liang, Zhen1; Zhang, Lihua1; Zhang, Yukui1; Zhang LH(张丽华)
关键词Chiral Separation Sub-2 Mu m Superficially Porous Particles Native Amino Acids Teicoplanin
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2015-10-10
DOI10.1016/j.jpba.2015.05.035
114期:1页:247-253
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; CHIRAL STATIONARY PHASES ; MESOPOROUS SILICA PARTICLES ; CORE-SHELL ; COLUMN PERFORMANCE ; SEPARATION ; ENANTIOMERS ; SELECTORS ; SIZE
英文摘要Superficially porous particles (SPPs) demonstrate superior efficiency than totally porous particles in chiral separations. In order to obtain high efficiency and fast separation, sub-2 mu m SPPs with high surface area are synthesized, and with teicoplanin bonded, such materials are successfully applied into the rapid enantioseparation of native amino acids. In brief, 1.27 +/- 0.06 mu m nonporous silica particles are prepared by a modified seeded growth method, followed by mesoporous shell fabrication via one-pot templated dissolution and redeposition strategy, and pore size expansion via acid-refluxing. The diameter of the formed SPPs is 1.49 +/- 0.04 mu m, with the shell thickness as 206 nm. Nitrogen physisorption experiments show that the Brunauer-Emmett-Teller (BET) specific surface area is 213.6 m(2)/g and pore size is 9 nm. After teicoplanin derivatization with bonding capacity as 83.3 mu mol/g, the prepared chiral stationary phase is packed into a stainless steel tube with the geometry of 50 mm x 2.1 mm i.d.. In less than 6.4 min, six native amino acids (norleucine, alanine, valine, methionine, leucine, norvaline) are enantioseparated with resolution factors ranging from 1.9 to 5.0. Besides, the resolution for chiral separation is improved with ethanol-water instead of methanol-water as the mobile phase. Moreover, the low temperature gives higher resolution, but longer retention time and higher backpressure. Finally, the effect of flow rate on enantiomeric separation is studied and fast chiral separation within I min is obtained with flow rate of 0.4 mL/min. All these results show that the synthesized teicoplanin bonded sub-2 mu m SPPs have great potential to achieve the enantioseparation of native amino acids with high resolution and rapid speed. (C) 2015 Published by Elsevier B.V.
语种英语
WOS记录号WOS:000360780700035
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143708
专题中国科学院大连化学物理研究所
通讯作者Zhang LH(张丽华)
作者单位1.Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Min, Yi,Sui, Zhigang,Liang, Zhen,et al. Teicoplanin bonded sub-2 mu m superficially porous particles for enantioseparation of native amino acids[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015,114(1):247-253.
APA Min, Yi,Sui, Zhigang,Liang, Zhen,Zhang, Lihua,Zhang, Yukui,&张丽华.(2015).Teicoplanin bonded sub-2 mu m superficially porous particles for enantioseparation of native amino acids.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,114(1),247-253.
MLA Min, Yi,et al."Teicoplanin bonded sub-2 mu m superficially porous particles for enantioseparation of native amino acids".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 114.1(2015):247-253.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201584R1686skB.PDF(1347KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Min, Yi]的文章
[Sui, Zhigang]的文章
[Liang, Zhen]的文章
百度学术
百度学术中相似的文章
[Min, Yi]的文章
[Sui, Zhigang]的文章
[Liang, Zhen]的文章
必应学术
必应学术中相似的文章
[Min, Yi]的文章
[Sui, Zhigang]的文章
[Liang, Zhen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。