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学科主题物理化学
Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
Li, Yao-Guang1,2; Hou, Jie3; Li, Shi-Yang1; Lv, Xia1; Ning, Jing1,3; Wang, Ping1; Liu, Zhao-Ming1; Ge, Guang-Bo1; Ren, Jia-Yan2; Yang, Ling1; Ge GB(葛广波); Jia-YanRen; Yang L(杨凌)
关键词Fructus Psoraleae Human Carboxylesterase 2 Inhibitory Effects Lc-dad-esi-ms/ms
刊名FITOTERAPIA
2015-03-01
DOI10.1016/j.fitote.2015.01.004
101期:1页:99-106
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; CATALYTIC-PROPERTIES ; FLUORESCENT-PROBE ; BAKUCHIOL ; IRINOTECAN ; CPT-11 ; CONSTITUENTS ; HYDROLYSIS ; ACTIVATION ; COMPONENTS
英文摘要Fructus Psoraleae (FP) is an edible Chinese herbal which is widely used in Asia for the treatment of various diseases including asthma, diarrhea, and osteoporosis. This study aimed to investigate the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), as well as to identity and characterize the naturally occurring inhibitors of hCE2 in FP. Our results demonstrated that the ethanol extract of FP displayed potent inhibitory effects towards hCE2, while five major bioactive constitutes in FP were efficiently identified by LC-DAD-ESI-MS/MS, with the aid of LC-based activity profiling. The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62 mu M to 3.89 mu M. This is the first report of the chemical constitutes in FP as potent inhibitors of hCE2. (C) 2015 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000352252700014
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143758
专题中国科学院大连化学物理研究所
通讯作者Ge GB(葛广波); Jia-YanRen; Yang L(杨凌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China
3.Dalian Med Univ, Dalian 116044, Peoples R China
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GB/T 7714
Li, Yao-Guang,Hou, Jie,Li, Shi-Yang,et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2[J]. FITOTERAPIA,2015,101(1):99-106.
APA Li, Yao-Guang.,Hou, Jie.,Li, Shi-Yang.,Lv, Xia.,Ning, Jing.,...&杨凌.(2015).Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2.FITOTERAPIA,101(1),99-106.
MLA Li, Yao-Guang,et al."Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2".FITOTERAPIA 101.1(2015):99-106.
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