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学科主题: 物理化学
题名: Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
作者: Li, Yao-Guang1, 2;  Hou, Jie3;  Li, Shi-Yang1;  Lv, Xia1;  Ning, Jing1, 3;  Wang, Ping1;  Liu, Zhao-Ming1;  Ge, Guang-Bo1;  Ren, Jia-Yan2;  Yang, Ling1
通讯作者: 葛广波 ;  Jia-YanRen ;  杨凌
关键词: Fructus Psoraleae ;  Human carboxylesterase 2 ;  Inhibitory effects ;  LC-DAD-ESI-MS/MS
刊名: FITOTERAPIA
发表日期: 2015-03-01
DOI: 10.1016/j.fitote.2015.01.004
卷: 101, 期:1, 页:99-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Fructus Psoraleae (FP) is an edible Chinese herbal which is widely used in Asia for the treatment of various diseases including asthma, diarrhea, and osteoporosis. This study aimed to investigate the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), as well as to identity and characterize the naturally occurring inhibitors of hCE2 in FP. Our results demonstrated that the ethanol extract of FP displayed potent inhibitory effects towards hCE2, while five major bioactive constitutes in FP were efficiently identified by LC-DAD-ESI-MS/MS, with the aid of LC-based activity profiling. The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62 mu M to 3.89 mu M. This is the first report of the chemical constitutes in FP as potent inhibitors of hCE2. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  CATALYTIC-PROPERTIES ;  FLUORESCENT-PROBE ;  BAKUCHIOL ;  IRINOTECAN ;  CPT-11 ;  CONSTITUENTS ;  HYDROLYSIS ;  ACTIVATION ;  COMPONENTS
语种: 英语
WOS记录号: WOS:000352252700014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143758
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China
3.Dalian Med Univ, Dalian 116044, Peoples R China

Recommended Citation:
Li, Yao-Guang,Hou, Jie,Li, Shi-Yang,et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2[J]. FITOTERAPIA,2015,101(1):99-106.
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