DICP OpenIR
Subject Area物理化学
Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
Li, Yao-Guang1,2; Hou, Jie3; Li, Shi-Yang1; Lv, Xia1; Ning, Jing1,3; Wang, Ping1; Liu, Zhao-Ming1; Ge, Guang-Bo1; Ren, Jia-Yan2; Yang, Ling1; Ge GB(葛广波); Jia-YanRen; Yang L(杨凌)
KeywordFructus Psoraleae Human Carboxylesterase 2 Inhibitory Effects Lc-dad-esi-ms/ms
Source PublicationFITOTERAPIA
2015-03-01
DOI10.1016/j.fitote.2015.01.004
Volume101Issue:1Pages:99-106
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; CATALYTIC-PROPERTIES ; FLUORESCENT-PROBE ; BAKUCHIOL ; IRINOTECAN ; CPT-11 ; CONSTITUENTS ; HYDROLYSIS ; ACTIVATION ; COMPONENTS
AbstractFructus Psoraleae (FP) is an edible Chinese herbal which is widely used in Asia for the treatment of various diseases including asthma, diarrhea, and osteoporosis. This study aimed to investigate the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), as well as to identity and characterize the naturally occurring inhibitors of hCE2 in FP. Our results demonstrated that the ethanol extract of FP displayed potent inhibitory effects towards hCE2, while five major bioactive constitutes in FP were efficiently identified by LC-DAD-ESI-MS/MS, with the aid of LC-based activity profiling. The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62 mu M to 3.89 mu M. This is the first report of the chemical constitutes in FP as potent inhibitors of hCE2. (C) 2015 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000352252700014
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143758
Collection中国科学院大连化学物理研究所
Corresponding AuthorGe GB(葛广波); Jia-YanRen; Yang L(杨凌)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China
3.Dalian Med Univ, Dalian 116044, Peoples R China
Recommended Citation
GB/T 7714
Li, Yao-Guang,Hou, Jie,Li, Shi-Yang,et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2[J]. FITOTERAPIA,2015,101(1):99-106.
APA Li, Yao-Guang.,Hou, Jie.,Li, Shi-Yang.,Lv, Xia.,Ning, Jing.,...&杨凌.(2015).Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2.FITOTERAPIA,101(1),99-106.
MLA Li, Yao-Guang,et al."Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2".FITOTERAPIA 101.1(2015):99-106.
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