DICP OpenIR
Subject Area物理化学
A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography
Zhang, Haiyang1,2; Ou, Junjie2; Wei, Yinmao1; Wang, Hongwei2,3; Liu, Zhongshan2,3; Chen, Lianfang2,3; Zou, Hanfa2; Ou JJ(欧俊杰); Wei YM(卫引茂); Zou HF(邹汉法)
KeywordPolymer Monoliths Capillary Liquid Chromatography Dipentaerythritol Penta-/hexa-acrylate Photo-initiated Polymerization
Source PublicationANALYTICA CHIMICA ACTA
2015-07-09
DOI10.1016/j.aca.2015.04.001
Volume883Issue:1Pages:90-98
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordRING-OPENING POLYMERIZATION ; LESS COMMON APPLICATIONS ; LARGE SURFACE-AREA ; METHACRYLATE MONOLITHS ; STATIONARY PHASES ; POROUS PROPERTIES ; HYBRID MONOLITH ; COLUMNS ; HPLC ; PERFORMANCE
AbstractLow column efficiency for small molecules in reversed-phase chromatography is a major problem commonly encountered in polymer-based monoliths. Herein, a novel highly crosslinked porous polymeric monolith was in situ prepared by using a multi-acrylate monomer, dipentaerythritol penta-/hexa-acrylate (DPEPA), as crosslinker, which copolymerized with lauryl methacrylate (LMA) as functional monomer in a UV-transparent fused-silica capillary via photo-initiated free-radical polymerization within 5 min. The mechanical stability and permeability of the resulting poly(LMA-co-DPEPA) monolith were characterized in detail. One series of highly crosslinked poly(LMA-co-DPEPA) columns were prepared with relatively higher content of crosslinker (63.3%) in the precursor. Although they exhibited lower permeability, high column efficiency for alkylbenzenes was acquired in cLC, and the minimum plate height (column B) was in the range of 6.04-9.00 mm, corresponding to 111,000-165,000 N m(-1). Meanwhile, another series of poly(LMA-co-DPEPA) columns prepared with relatively lower content of crosslinker (52.7%) in the precursor exhibited higher permeability, but the minimum plate height (column E) was relatively low in the range of 10.75-20.04 mm for alkylbenzenes, corresponding to 50,000-93,000 N m(-1). Compared with common poly(LMA-co-EDMA) columns previously reported, the highly crosslinked poly(LMA-co-DPEPA) columns using a multi-acrylate monomer as crosslinker possessed remarkably high column efficiency for small molecules in cLC. By plotting of plate height (H) of alkylbenzenes versus the linear velocity (u) of mobile phase, the results revealed a retention-independent efficient performance of small molecules in the isocratic elution, indicating that the use of multi-functional crosslinker possibly prevents the generation of gel-like micropores in the poly(LMA-co-DPEPA) monolith, reducing the mass transfer resistance (C-term). (C) 2015 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000356236700011
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143773
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu JJ(欧俊杰); Wei YM(卫引茂); Zou HF(邹汉法)
Affiliation1.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Haiyang,Ou, Junjie,Wei, Yinmao,et al. A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2015,883(1):90-98.
APA Zhang, Haiyang.,Ou, Junjie.,Wei, Yinmao.,Wang, Hongwei.,Liu, Zhongshan.,...&邹汉法.(2015).A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography.ANALYTICA CHIMICA ACTA,883(1),90-98.
MLA Zhang, Haiyang,et al."A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography".ANALYTICA CHIMICA ACTA 883.1(2015):90-98.
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