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学科主题物理化学
A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography
Zhang, Haiyang1,2; Ou, Junjie2; Wei, Yinmao1; Wang, Hongwei2,3; Liu, Zhongshan2,3; Chen, Lianfang2,3; Zou, Hanfa2; Ou JJ(欧俊杰); Wei YM(卫引茂); Zou HF(邹汉法)
关键词Polymer Monoliths Capillary Liquid Chromatography Dipentaerythritol Penta-/hexa-acrylate Photo-initiated Polymerization
刊名ANALYTICA CHIMICA ACTA
2015-07-09
DOI10.1016/j.aca.2015.04.001
883期:1页:90-98
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]RING-OPENING POLYMERIZATION ; LESS COMMON APPLICATIONS ; LARGE SURFACE-AREA ; METHACRYLATE MONOLITHS ; STATIONARY PHASES ; POROUS PROPERTIES ; HYBRID MONOLITH ; COLUMNS ; HPLC ; PERFORMANCE
英文摘要Low column efficiency for small molecules in reversed-phase chromatography is a major problem commonly encountered in polymer-based monoliths. Herein, a novel highly crosslinked porous polymeric monolith was in situ prepared by using a multi-acrylate monomer, dipentaerythritol penta-/hexa-acrylate (DPEPA), as crosslinker, which copolymerized with lauryl methacrylate (LMA) as functional monomer in a UV-transparent fused-silica capillary via photo-initiated free-radical polymerization within 5 min. The mechanical stability and permeability of the resulting poly(LMA-co-DPEPA) monolith were characterized in detail. One series of highly crosslinked poly(LMA-co-DPEPA) columns were prepared with relatively higher content of crosslinker (63.3%) in the precursor. Although they exhibited lower permeability, high column efficiency for alkylbenzenes was acquired in cLC, and the minimum plate height (column B) was in the range of 6.04-9.00 mm, corresponding to 111,000-165,000 N m(-1). Meanwhile, another series of poly(LMA-co-DPEPA) columns prepared with relatively lower content of crosslinker (52.7%) in the precursor exhibited higher permeability, but the minimum plate height (column E) was relatively low in the range of 10.75-20.04 mm for alkylbenzenes, corresponding to 50,000-93,000 N m(-1). Compared with common poly(LMA-co-EDMA) columns previously reported, the highly crosslinked poly(LMA-co-DPEPA) columns using a multi-acrylate monomer as crosslinker possessed remarkably high column efficiency for small molecules in cLC. By plotting of plate height (H) of alkylbenzenes versus the linear velocity (u) of mobile phase, the results revealed a retention-independent efficient performance of small molecules in the isocratic elution, indicating that the use of multi-functional crosslinker possibly prevents the generation of gel-like micropores in the poly(LMA-co-DPEPA) monolith, reducing the mass transfer resistance (C-term). (C) 2015 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000356236700011
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143773
专题中国科学院大连化学物理研究所
通讯作者Ou JJ(欧俊杰); Wei YM(卫引茂); Zou HF(邹汉法)
作者单位1.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Haiyang,Ou, Junjie,Wei, Yinmao,et al. A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2015,883(1):90-98.
APA Zhang, Haiyang.,Ou, Junjie.,Wei, Yinmao.,Wang, Hongwei.,Liu, Zhongshan.,...&邹汉法.(2015).A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography.ANALYTICA CHIMICA ACTA,883(1),90-98.
MLA Zhang, Haiyang,et al."A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography".ANALYTICA CHIMICA ACTA 883.1(2015):90-98.
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