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学科主题: 物理化学
题名: Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer
作者: Wan, Hao1, 2;  Zhang, Yi1;  Zhang, Weibing2;  Zou, Hanfa1
通讯作者: 张维冰 ;  邹汉法
关键词: two-photon imaging ;  dual targeting ;  pH-triggered release ;  chemo-photodynamic synergistic treatment ;  multifunctional nanocarrier
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015-05-13
DOI: 10.1021/acsami.5b01165
卷: 7, 期:18, 页:9608-9618
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ;  Materials Science
英文摘要: In consideration of the intrinsic complexity of cancer, just being a delivery nanovehicle for the nanocarrier is no longer enough to fulfill requirements of dealing with cancer. In this regard, the multifunctional nanocarrier appears to be an appealing choice in cancer treatment. Herein, the novel multifunctional nanocarrier (Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD) possessing properties of dual targeting (the peptide- and magnetism-mediated targeting), imaging (one- and two-photon modes), pH-triggered release of loaded anticancer drug, and synergistic treatment (photodynamic therapy (PDT) combined with chemotherapy) are successfully developed. The nanocarrier specifically centralizes within cancer cells with the enhanced amount through the dual targeting ability and is facilely tracked under one- and two-photon imaging modes attributed to the autofluorescence. Then, visible light irradiation-induced PDT combined with low pH-triggered chemotherapy synergistically cooperate to efficiently kill cancer cells. Following the above process, the multifunctional nanocarrier demonstrates effective inhibition of the growth of A549 and HeLa cancer cells. The efficient manipulation of Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD also implies potential applications of the multifunctional nanocarrier in delivery of different agents. Furthermore, it might also broaden the scope of fabrication of the multifunctional nanocarrier for inhibiting the growth of cancer cells.
关键词[WOS]: CARBON NITRIDE NANOSHEETS ;  MODIFIED SILICA NANOPARTICLES ;  CORE-SHELL NANOCOMPOSITES ;  PHASE C3N4 NANOSHEETS ;  NEAR-INFRARED LIGHT ;  IN-VIVO ;  VISIBLE-LIGHT ;  QUANTUM DOTS ;  PHOTOCATALYTIC ACTIVITIES ;  PHOTOTHERMAL THERAPY
语种: 英语
WOS记录号: WOS:000354906500033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143779
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

Recommended Citation:
Wan, Hao,Zhang, Yi,Zhang, Weibing,et al. Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(18):9608-9618.
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