DICP OpenIR
Subject Area物理化学
Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer
Wan, Hao1,2; Zhang, Yi1; Zhang, Weibing2; Zou, Hanfa1; Zhang WB(张维冰); Zou HF(邹汉法)
KeywordTwo-photon Imaging Dual Targeting Ph-triggered Release Chemo-photodynamic Synergistic Treatment Multifunctional Nanocarrier
Source PublicationACS APPLIED MATERIALS & INTERFACES
2015-05-13
DOI10.1021/acsami.5b01165
Volume7Issue:18Pages:9608-9618
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS KeywordCARBON NITRIDE NANOSHEETS ; MODIFIED SILICA NANOPARTICLES ; CORE-SHELL NANOCOMPOSITES ; PHASE C3N4 NANOSHEETS ; NEAR-INFRARED LIGHT ; IN-VIVO ; VISIBLE-LIGHT ; QUANTUM DOTS ; PHOTOCATALYTIC ACTIVITIES ; PHOTOTHERMAL THERAPY
AbstractIn consideration of the intrinsic complexity of cancer, just being a delivery nanovehicle for the nanocarrier is no longer enough to fulfill requirements of dealing with cancer. In this regard, the multifunctional nanocarrier appears to be an appealing choice in cancer treatment. Herein, the novel multifunctional nanocarrier (Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD) possessing properties of dual targeting (the peptide- and magnetism-mediated targeting), imaging (one- and two-photon modes), pH-triggered release of loaded anticancer drug, and synergistic treatment (photodynamic therapy (PDT) combined with chemotherapy) are successfully developed. The nanocarrier specifically centralizes within cancer cells with the enhanced amount through the dual targeting ability and is facilely tracked under one- and two-photon imaging modes attributed to the autofluorescence. Then, visible light irradiation-induced PDT combined with low pH-triggered chemotherapy synergistically cooperate to efficiently kill cancer cells. Following the above process, the multifunctional nanocarrier demonstrates effective inhibition of the growth of A549 and HeLa cancer cells. The efficient manipulation of Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD also implies potential applications of the multifunctional nanocarrier in delivery of different agents. Furthermore, it might also broaden the scope of fabrication of the multifunctional nanocarrier for inhibiting the growth of cancer cells.
Language英语
WOS IDWOS:000354906500033
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143779
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang WB(张维冰); Zou HF(邹汉法)
Affiliation1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Wan, Hao,Zhang, Yi,Zhang, Weibing,et al. Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(18):9608-9618.
APA Wan, Hao,Zhang, Yi,Zhang, Weibing,Zou, Hanfa,张维冰,&邹汉法.(2015).Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer.ACS APPLIED MATERIALS & INTERFACES,7(18),9608-9618.
MLA Wan, Hao,et al."Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer".ACS APPLIED MATERIALS & INTERFACES 7.18(2015):9608-9618.
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