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学科主题: 物理化学
题名: Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles
作者: Hu, Zhengyan1, 2;  Zhang, Hongyan1, 2;  Zhang, Yi1, 2;  Wu, Ren'an1;  Zou, Hanfa1
通讯作者: 吴仁安 ;  邹汉法
关键词: Protein corona ;  Fe3O4 NPs ;  Particle size ;  Quantitative proteomics
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2014-09-01
DOI: 10.1016/j.colsurfb.2014.06.016
卷: 121, 期:1, 页:354-361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biophysics ;  Chemistry, Physical ;  Materials Science, Biomaterials
研究领域[WOS]: Biophysics ;  Chemistry ;  Materials Science
英文摘要: When nanoparticles (NPs) enter into biological systems, proteins would interact with NPs to form the protein corona that can critically impact the biological identity of the nanomaterial. Owing to their fundamental scientific interest and potential applications, Fe3O4 NPs of different sizes have been developed for applications in cell separation and protein separation and as contrast agents in magnetic resonance imaging (MRI), etc. Here, we investigated whether nanoparticle size affects the formation of protein coronas around Fe3O4 NPs. Both the identification and quantification results demonstrated that particle size does play an important role in the formation of plasma protein coronas on Fe3O4 NPs; it not only influenced the protein composition of the formed plasma protein corona but also affected the abundances of the plasma proteins within the coronas. Understanding the different binding profiles of human plasma proteins on Fe3O4 NPs of different sizes would facilitate the exploration of the bio-distributions and biological fates of Fe3O4 NPs in biological systems. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: IRON-OXIDE NANOPARTICLES ;  MAGNETIC NANOPARTICLES ;  QUANTITATIVE PROTEOMICS ;  MOLECULAR INTERACTION ;  SURFACE-PROPERTIES ;  MACROPHAGE UPTAKE ;  NANOMATERIALS ;  IMPACT ;  CELLS ;  IDENTIFICATION
语种: 英语
WOS记录号: WOS:000341335800043
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143813
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Hu, Zhengyan,Zhang, Hongyan,Zhang, Yi,et al. Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,121(1):354-361.
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