DICP OpenIR
Subject Area物理化学
Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles
Hu, Zhengyan1,2; Zhang, Hongyan1,2; Zhang, Yi1,2; Wu, Ren'an1; Zou, Hanfa1; Wu RA(吴仁安); Zou HF(邹汉法)
KeywordProtein Corona Fe3o4 Nps Particle Size Quantitative Proteomics
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
2014-09-01
DOI10.1016/j.colsurfb.2014.06.016
Volume121Issue:1Pages:354-361
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS KeywordIRON-OXIDE NANOPARTICLES ; MAGNETIC NANOPARTICLES ; QUANTITATIVE PROTEOMICS ; MOLECULAR INTERACTION ; SURFACE-PROPERTIES ; MACROPHAGE UPTAKE ; NANOMATERIALS ; IMPACT ; CELLS ; IDENTIFICATION
AbstractWhen nanoparticles (NPs) enter into biological systems, proteins would interact with NPs to form the protein corona that can critically impact the biological identity of the nanomaterial. Owing to their fundamental scientific interest and potential applications, Fe3O4 NPs of different sizes have been developed for applications in cell separation and protein separation and as contrast agents in magnetic resonance imaging (MRI), etc. Here, we investigated whether nanoparticle size affects the formation of protein coronas around Fe3O4 NPs. Both the identification and quantification results demonstrated that particle size does play an important role in the formation of plasma protein coronas on Fe3O4 NPs; it not only influenced the protein composition of the formed plasma protein corona but also affected the abundances of the plasma proteins within the coronas. Understanding the different binding profiles of human plasma proteins on Fe3O4 NPs of different sizes would facilitate the exploration of the bio-distributions and biological fates of Fe3O4 NPs in biological systems. (C) 2014 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000341335800043
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143813
Collection中国科学院大连化学物理研究所
Corresponding AuthorWu RA(吴仁安); Zou HF(邹汉法)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zhengyan,Zhang, Hongyan,Zhang, Yi,et al. Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,121(1):354-361.
APA Hu, Zhengyan.,Zhang, Hongyan.,Zhang, Yi.,Wu, Ren'an.,Zou, Hanfa.,...&邹汉法.(2014).Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles.COLLOIDS AND SURFACES B-BIOINTERFACES,121(1),354-361.
MLA Hu, Zhengyan,et al."Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles".COLLOIDS AND SURFACES B-BIOINTERFACES 121.1(2014):354-361.
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