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学科主题物理化学
Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles
Hu, Zhengyan1,2; Zhang, Hongyan1,2; Zhang, Yi1,2; Wu, Ren'an1; Zou, Hanfa1; Wu RA(吴仁安); Zou HF(邹汉法)
关键词Protein Corona Fe3o4 Nps Particle Size Quantitative Proteomics
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2014-09-01
DOI10.1016/j.colsurfb.2014.06.016
121期:1页:354-361
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]IRON-OXIDE NANOPARTICLES ; MAGNETIC NANOPARTICLES ; QUANTITATIVE PROTEOMICS ; MOLECULAR INTERACTION ; SURFACE-PROPERTIES ; MACROPHAGE UPTAKE ; NANOMATERIALS ; IMPACT ; CELLS ; IDENTIFICATION
英文摘要When nanoparticles (NPs) enter into biological systems, proteins would interact with NPs to form the protein corona that can critically impact the biological identity of the nanomaterial. Owing to their fundamental scientific interest and potential applications, Fe3O4 NPs of different sizes have been developed for applications in cell separation and protein separation and as contrast agents in magnetic resonance imaging (MRI), etc. Here, we investigated whether nanoparticle size affects the formation of protein coronas around Fe3O4 NPs. Both the identification and quantification results demonstrated that particle size does play an important role in the formation of plasma protein coronas on Fe3O4 NPs; it not only influenced the protein composition of the formed plasma protein corona but also affected the abundances of the plasma proteins within the coronas. Understanding the different binding profiles of human plasma proteins on Fe3O4 NPs of different sizes would facilitate the exploration of the bio-distributions and biological fates of Fe3O4 NPs in biological systems. (C) 2014 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000341335800043
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143813
专题中国科学院大连化学物理研究所
通讯作者Wu RA(吴仁安); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Hu, Zhengyan,Zhang, Hongyan,Zhang, Yi,et al. Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,121(1):354-361.
APA Hu, Zhengyan.,Zhang, Hongyan.,Zhang, Yi.,Wu, Ren'an.,Zou, Hanfa.,...&邹汉法.(2014).Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles.COLLOIDS AND SURFACES B-BIOINTERFACES,121(1),354-361.
MLA Hu, Zhengyan,et al."Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles".COLLOIDS AND SURFACES B-BIOINTERFACES 121.1(2014):354-361.
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