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学科主题物理化学
A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells
Qiao, Qinglong1,2; Zhao, Miao2; Lang, Haijing2; Mao, Deqi1,2; Cui, Jingnan1; Xu, Zhaochao1,2; Xu ZC(徐兆超); Cui JN(崔京南)
刊名RSC ADVANCES
2014
DOI10.1039/c4ra03725a
4期:49页:25790-25794
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]2-PHOTON PROBE ; LIVE CELLS ; ZINC ; PH ; ACTIVATION ; MECHANISMS ; SIGNALS ; SENSORS ; TUMORS ; ZN2+
英文摘要Hydrogen sulfide (H2S) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. H2S can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. In this study, we developed a lysosome-targetable fluorescent probe for the recognition of H2S with considerable fluorescence enhancement. Through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the H2S probe N-imide termus of 4-azide-1,8-naphthalimide, the new compound Lyso-AFP can recognize H2S in lysosomes. This probe emerges as a more biocompatible analysis tool with low poison by-product than reported H2S fluorescent probes.
语种英语
WOS记录号WOS:000338434500038
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/143918
专题中国科学院大连化学物理研究所
通讯作者Xu ZC(徐兆超); Cui JN(崔京南)
作者单位1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China
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Qiao, Qinglong,Zhao, Miao,Lang, Haijing,et al. A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J]. RSC ADVANCES,2014,4(49):25790-25794.
APA Qiao, Qinglong.,Zhao, Miao.,Lang, Haijing.,Mao, Deqi.,Cui, Jingnan.,...&崔京南.(2014).A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells.RSC ADVANCES,4(49),25790-25794.
MLA Qiao, Qinglong,et al."A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells".RSC ADVANCES 4.49(2014):25790-25794.
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