中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells
作者: Qiao, Qinglong1, 2;  Zhao, Miao2;  Lang, Haijing2;  Mao, Deqi1, 2;  Cui, Jingnan1;  Xu, Zhaochao1, 2
通讯作者: 徐兆超 ;  崔京南
刊名: RSC ADVANCES
发表日期: 2014
DOI: 10.1039/c4ra03725a
卷: 4, 期:49, 页:25790-25794
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Hydrogen sulfide (H2S) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. H2S can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. In this study, we developed a lysosome-targetable fluorescent probe for the recognition of H2S with considerable fluorescence enhancement. Through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the H2S probe N-imide termus of 4-azide-1,8-naphthalimide, the new compound Lyso-AFP can recognize H2S in lysosomes. This probe emerges as a more biocompatible analysis tool with low poison by-product than reported H2S fluorescent probes.
关键词[WOS]: 2-PHOTON PROBE ;  LIVE CELLS ;  ZINC ;  PH ;  ACTIVATION ;  MECHANISMS ;  SIGNALS ;  SENSORS ;  TUMORS ;  ZN2+
语种: 英语
WOS记录号: WOS:000338434500038
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/143918
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2014W4eq8MzzTQ.PDF(944KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China

Recommended Citation:
Qiao, Qinglong,Zhao, Miao,Lang, Haijing,et al. A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J]. RSC ADVANCES,2014,4(49):25790-25794.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Qiao, Qinglong]'s Articles
 [Zhao, Miao]'s Articles
 [Lang, Haijing]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Qiao, Qinglong]‘s Articles
 [Zhao, Miao]‘s Articles
 [Lang, Haijing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2014W4eq8MzzTQ.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace