DICP OpenIR
Subject Area物理化学
A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells
Qiao, Qinglong1,2; Zhao, Miao2; Lang, Haijing2; Mao, Deqi1,2; Cui, Jingnan1; Xu, Zhaochao1,2; Xu ZC(徐兆超); Cui JN(崔京南)
Source PublicationRSC ADVANCES
2014
DOI10.1039/c4ra03725a
Volume4Issue:49Pages:25790-25794
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS Keyword2-PHOTON PROBE ; LIVE CELLS ; ZINC ; PH ; ACTIVATION ; MECHANISMS ; SIGNALS ; SENSORS ; TUMORS ; ZN2+
AbstractHydrogen sulfide (H2S) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. H2S can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. In this study, we developed a lysosome-targetable fluorescent probe for the recognition of H2S with considerable fluorescence enhancement. Through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the H2S probe N-imide termus of 4-azide-1,8-naphthalimide, the new compound Lyso-AFP can recognize H2S in lysosomes. This probe emerges as a more biocompatible analysis tool with low poison by-product than reported H2S fluorescent probes.
Language英语
WOS IDWOS:000338434500038
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/143918
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu ZC(徐兆超); Cui JN(崔京南)
Affiliation1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Qinglong,Zhao, Miao,Lang, Haijing,et al. A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J]. RSC ADVANCES,2014,4(49):25790-25794.
APA Qiao, Qinglong.,Zhao, Miao.,Lang, Haijing.,Mao, Deqi.,Cui, Jingnan.,...&崔京南.(2014).A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells.RSC ADVANCES,4(49),25790-25794.
MLA Qiao, Qinglong,et al."A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells".RSC ADVANCES 4.49(2014):25790-25794.
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