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学科主题物理化学
Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase
Zhang, Yixin1,2,3; Liu, Wujun1,2; Zhao, Zongbao K.1,2; Zhao ZB(赵宗保)
关键词Photolysis Tetrazole Nucleophilic Addition Aqueous-phase Reaction Nitrilimine Bioorthogonal Reaction
刊名MOLECULES
2014
DOI10.3390/molecules19010306
19期:1页:306-315
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]1,3-DIPOLAR CYCLOADDITION ; 2,5-DISUBSTITUTED TETRAZOLES ; PROTEINS ; IMINES ; PHOTOCHEMISTRY ; DERIVATIVES ; CHEMISTRY ; CELLS
英文摘要Nitrilimine generated by photolysis of diaryltetrazole in aqueous phase under mild conditions was trapped by nucleophiles including amines and thioalcohols. The representative products were characterized, while products with all 20 natural amino acids and a peptide were observed by MALDI-TOF mass spectroscopy. Competitive studies showed that this reaction also occurred in the presence of acrylamide. These results provided new information for understanding the potential side reactions when tetrazole-alkene pairs were used as a bioorthogonal reaction in labeling proteins and related studies in buffered systems.
语种英语
WOS记录号WOS:000334420300019
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144044
专题中国科学院大连化学物理研究所
通讯作者Zhao ZB(赵宗保)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Zhang, Yixin,Liu, Wujun,Zhao, Zongbao K.,et al. Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase[J]. MOLECULES,2014,19(1):306-315.
APA Zhang, Yixin,Liu, Wujun,Zhao, Zongbao K.,&赵宗保.(2014).Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase.MOLECULES,19(1),306-315.
MLA Zhang, Yixin,et al."Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase".MOLECULES 19.1(2014):306-315.
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