DICP OpenIR
Subject Area物理化学
Tunable Bronsted Acidity-Dependent Alkylation and Alkenylation of Indoles
Wu, Kaikai1; Wu, Ping1; Wang, Liandi1; Chen, Jiping1; Sun, Chenglin1; Yu, Zhengkun1,2; Yu ZK(余正坤)
KeywordAlkenylation Alkylation Bronsted Acids 3-(Dimethylamino)Acrylonitrile Indoles
Source PublicationADVANCED SYNTHESIS & CATALYSIS
2014-12-15
DOI10.1002/adsc.201400477
Volume356Issue:18Pages:3871-3880
Indexed BySCI ; IC
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS Research AreaChemistry
WOS KeywordC-H ACTIVATION ; BOND ACTIVATION ; PRACTICAL SYNTHESIS ; FUNCTIONALIZATION ; ALKENES ; C2-ALKENYLATION ; 2-ALKYLATION ; DERIVATIVES ; OLEFINATION ; ALDEHYDES
AbstractThe Bronsted acid-mediated alkylation and alkenylation of indoles were efficiently achieved by means of 3-(dimethylamino)acrylonitrile. Regulating the acidity of the reaction medium with para-toluenesulfonic acid monohydrate (p-TsOH center dot H2O) and/or acetic acid (HOAc) led to versatile formation of 3-alkylated and 3-alkenylated indole derivatives under mild conditions. The 3-alkylated indole products could be nearly quantitatively transformed to the corresponding separable (E)- and (Z)-3-alkenylated indoles.
Language英语
WOS IDWOS:000346071600020
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144082
Collection中国科学院大连化学物理研究所
Corresponding AuthorYu ZK(余正坤)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
Recommended Citation
GB/T 7714
Wu, Kaikai,Wu, Ping,Wang, Liandi,et al. Tunable Bronsted Acidity-Dependent Alkylation and Alkenylation of Indoles[J]. ADVANCED SYNTHESIS & CATALYSIS,2014,356(18):3871-3880.
APA Wu, Kaikai.,Wu, Ping.,Wang, Liandi.,Chen, Jiping.,Sun, Chenglin.,...&余正坤.(2014).Tunable Bronsted Acidity-Dependent Alkylation and Alkenylation of Indoles.ADVANCED SYNTHESIS & CATALYSIS,356(18),3871-3880.
MLA Wu, Kaikai,et al."Tunable Bronsted Acidity-Dependent Alkylation and Alkenylation of Indoles".ADVANCED SYNTHESIS & CATALYSIS 356.18(2014):3871-3880.
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