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学科主题: 物理化学
题名: Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling
作者: Li, Yu1, 2;  Xu, Qingsong1;  Wei, Peng1, 2;  Cheng, Likun1, 2;  Peng, Qiang1, 2;  Li, Shuguang1;  Yin, Heng1;  Du, Yuguang1
通讯作者: 杜昱光 ;  尹恒
关键词: mitogen- activated protein kinase ;  nuclear factor-kappa B ;  lipopolysaccharide ;  molecular adhesion ;  chitosan oligosaccharides
刊名: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
发表日期: 2014-02-01
DOI: 10.3892/ijmm.2013.1589
卷: 33, 期:2, 页:392-400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
英文摘要: The expression of adhesion molecules in endothelial cells elicited by lipopolysaccharide (LPS) is involved in the adhesive interaction between endothelial cells and monocytes in inflammation. In this study, in order to characterize the anti-inflammatory effects of chitosan oligosaccharides (COS) on LPS-induced inflammation and to elucidate the underlying mechanisms, the mRNA levels of E-selectin and intercellular adhesion molecule-1 (ICAM-1) were measured in porcine iliac artery endothelial cells (PIECs). When these cells were treated with COS, the LPS-induced mRNA expression of E-selectin and ICAM-1 was reduced through the inhibition of the signal transduction cascade, p38 mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinase 1/2 (ERK1/2) and nuclear factor-kappa B (NF-kappa B). Moreover, through the inhibition of p38 MAPK and ERK1/2, COS suppressed the LPS-induced NF-kappa B p65 translocation. We found that COS suppressed the phosphorylation of p38 MAPK and the translocation of NF-kappa B p65 into the nucleus in a dose-dependent manner, and inhibited the adhesion of U973 cells to PIECs. Based on these results, it can be concluded that COS downregulate the expression of E-selectin and ICAM-1 by inhibiting the phosphorylation of MAPKs and the activation of NF-kappa B in LPS-treated PIECs. Our study demonstrates the valuable anti-inflammatory properties of COS.
关键词[WOS]: NF-KAPPA-B ;  PERIODONTAL-LIGAMENT CELLS ;  ADHESION MOLECULE-1 ;  IN-VITRO ;  CHITOOLIGOSACCHARIDES ;  LIPOPOLYSACCHARIDE ;  GLUCOSAMINE ;  PATHWAY ;  ACTIVATION ;  MECHANISMS
语种: 英语
WOS记录号: WOS:000332687000017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144142
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Li, Yu,Xu, Qingsong,Wei, Peng,et al. Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2014,33(2):392-400.
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