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学科主题物理化学
Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling
Li, Yu1,2; Xu, Qingsong1; Wei, Peng1,2; Cheng, Likun1,2; Peng, Qiang1,2; Li, Shuguang1; Yin, Heng1; Du, Yuguang1; Du YG(杜昱光); Yin H(尹恒)
关键词Mitogen- Activated Protein Kinase Nuclear Factor-kappa b Lipopolysaccharide Molecular Adhesion Chitosan Oligosaccharides
刊名INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2014-02-01
DOI10.3892/ijmm.2013.1589
33期:2页:392-400
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]NF-KAPPA-B ; PERIODONTAL-LIGAMENT CELLS ; ADHESION MOLECULE-1 ; IN-VITRO ; CHITOOLIGOSACCHARIDES ; LIPOPOLYSACCHARIDE ; GLUCOSAMINE ; PATHWAY ; ACTIVATION ; MECHANISMS
英文摘要The expression of adhesion molecules in endothelial cells elicited by lipopolysaccharide (LPS) is involved in the adhesive interaction between endothelial cells and monocytes in inflammation. In this study, in order to characterize the anti-inflammatory effects of chitosan oligosaccharides (COS) on LPS-induced inflammation and to elucidate the underlying mechanisms, the mRNA levels of E-selectin and intercellular adhesion molecule-1 (ICAM-1) were measured in porcine iliac artery endothelial cells (PIECs). When these cells were treated with COS, the LPS-induced mRNA expression of E-selectin and ICAM-1 was reduced through the inhibition of the signal transduction cascade, p38 mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinase 1/2 (ERK1/2) and nuclear factor-kappa B (NF-kappa B). Moreover, through the inhibition of p38 MAPK and ERK1/2, COS suppressed the LPS-induced NF-kappa B p65 translocation. We found that COS suppressed the phosphorylation of p38 MAPK and the translocation of NF-kappa B p65 into the nucleus in a dose-dependent manner, and inhibited the adhesion of U973 cells to PIECs. Based on these results, it can be concluded that COS downregulate the expression of E-selectin and ICAM-1 by inhibiting the phosphorylation of MAPKs and the activation of NF-kappa B in LPS-treated PIECs. Our study demonstrates the valuable anti-inflammatory properties of COS.
语种英语
WOS记录号WOS:000332687000017
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144142
专题中国科学院大连化学物理研究所
通讯作者Du YG(杜昱光); Yin H(尹恒)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Li, Yu,Xu, Qingsong,Wei, Peng,et al. Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2014,33(2):392-400.
APA Li, Yu.,Xu, Qingsong.,Wei, Peng.,Cheng, Likun.,Peng, Qiang.,...&尹恒.(2014).Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,33(2),392-400.
MLA Li, Yu,et al."Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 33.2(2014):392-400.
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