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学科主题: 物理化学
题名: Cytotoxic biflavones from Stellera chamaejasme
作者: Wang, Zhi-xin1;  Cheng, Meng-chun1;  Zhang, Xiao-zhe1;  Hong, Zhi-lai1;  Gao, Ming-zhe1;  Kan, Xiao-xi2;  Li, Qi2;  Wang, Ya-jie2;  Zhu, Xiao-xin2;  Xiao, Hong-bin1, 2
通讯作者: 肖红斌
关键词: Stellera chamaejasme ;  Chamaejasmenin E ;  Chamaejasmin D ;  LCD ;  Cytotoxic activity
刊名: FITOTERAPIA
发表日期: 2014-12-01
DOI: 10.1016/j.fitote.2014.10.002
卷: 99, 期:1, 页:334-340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Bioassay-guided phytochemical studies on Stellera chamaejasme led to the isolation of two new biflavones, chamaejasmenin E (1) and chamaejasmin D (2), together with ten known compounds. The structures of new compounds were elucidated by extensive spectroscopic analyses and their absolute configurations on 2, 3, 2 '' and 3 '' were confirmed by TDDFT quantum chemical calculated ECD spectra combined with experimental ECD spectra. All isolated biflavones were evaluated for their cytotoxic activities against Bel-7402 and A549 tumor cell lines, and sikokianin D (3) was found to possess the most potential cytotoxic activities against both the two cell lines with IC50 values of 1.29 +/- 021 and 0.75 +/- 025 mu M, respectively. Moreover, some structure function relationships of these bioflavones for cytotoxic activities were explored and summarized. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: CIRCULAR-DICHROISM ;  NEOCHAMAEJASMIN-A ;  CANCER-CELLS ;  FLAVONOIDS ;  APOPTOSIS ;  BIFLAVANONES ;  CYCLE
语种: 英语
WOS记录号: WOS:000347019000042
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144159
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

Recommended Citation:
Wang, Zhi-xin,Cheng, Meng-chun,Zhang, Xiao-zhe,et al. Cytotoxic biflavones from Stellera chamaejasme[J]. FITOTERAPIA,2014,99(1):334-340.
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