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学科主题物理化学
Cytotoxic biflavones from Stellera chamaejasme
Wang, Zhi-xin1; Cheng, Meng-chun1; Zhang, Xiao-zhe1; Hong, Zhi-lai1; Gao, Ming-zhe1; Kan, Xiao-xi2; Li, Qi2; Wang, Ya-jie2; Zhu, Xiao-xin2; Xiao, Hong-bin1,2; Xiao HB(肖红斌)
关键词Stellera Chamaejasme Chamaejasmenin e Chamaejasmin d Lcd Cytotoxic Activity
刊名FITOTERAPIA
2014-12-01
DOI10.1016/j.fitote.2014.10.002
99期:1页:334-340
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CIRCULAR-DICHROISM ; NEOCHAMAEJASMIN-A ; CANCER-CELLS ; FLAVONOIDS ; APOPTOSIS ; BIFLAVANONES ; CYCLE
英文摘要Bioassay-guided phytochemical studies on Stellera chamaejasme led to the isolation of two new biflavones, chamaejasmenin E (1) and chamaejasmin D (2), together with ten known compounds. The structures of new compounds were elucidated by extensive spectroscopic analyses and their absolute configurations on 2, 3, 2 '' and 3 '' were confirmed by TDDFT quantum chemical calculated ECD spectra combined with experimental ECD spectra. All isolated biflavones were evaluated for their cytotoxic activities against Bel-7402 and A549 tumor cell lines, and sikokianin D (3) was found to possess the most potential cytotoxic activities against both the two cell lines with IC50 values of 1.29 +/- 021 and 0.75 +/- 025 mu M, respectively. Moreover, some structure function relationships of these bioflavones for cytotoxic activities were explored and summarized. (C) 2014 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000347019000042
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144159
专题中国科学院大连化学物理研究所
通讯作者Xiao HB(肖红斌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
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Wang, Zhi-xin,Cheng, Meng-chun,Zhang, Xiao-zhe,et al. Cytotoxic biflavones from Stellera chamaejasme[J]. FITOTERAPIA,2014,99(1):334-340.
APA Wang, Zhi-xin.,Cheng, Meng-chun.,Zhang, Xiao-zhe.,Hong, Zhi-lai.,Gao, Ming-zhe.,...&肖红斌.(2014).Cytotoxic biflavones from Stellera chamaejasme.FITOTERAPIA,99(1),334-340.
MLA Wang, Zhi-xin,et al."Cytotoxic biflavones from Stellera chamaejasme".FITOTERAPIA 99.1(2014):334-340.
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