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学科主题: 物理化学
题名: Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth
作者: Liu, Yan-Qiu1, 2;  Yang, Qian-Xu2;  Cheng, Meng-Chun2;  Xiao, Hong-Bin2, 3
通讯作者: 肖红斌
关键词: Herba Epimedii ;  Icaritin ;  Icariside II ;  RAW264.7 ;  Synergy
刊名: PHYTOMEDICINE
发表日期: 2014-10-15
DOI: 10.1016/j.phymed.2014.07.016
卷: 21, 期:12, 页:1633-1637
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Increasing evidence shows the therapeutic superiority of herbal extracts in comparison to isolated single constituents. One of the reasons may be attributed to the synergy effect of compound combinations. Flavonoids from Herba Epimedii have been shown to have therapeutic effect against bone loss. Our previous study showed that Icariside II inhibited pre-osteoclast RAW264.7 growth. The aim of this study was to investigate whether the activity of Icariside II is synergized by other components of Herba Epimedii. The inhibitory activity of Icariside II was significantly enhanced in the presence of the extract of Herba Epimedii (EHE) at the ratio of 1:1, 1:5 and 1:10. Icaritin, another flavonoid constituent, was shown here to inhibit RAW264.7 growth in a dose-dependent manner. Further, we found that Icariside II, together with Icaritin, synergistically inhibited RAW264.7 growth. The synergistic effect is significant when the ratio of Icariside II and Icaritin was 10:1, 5:1, 1:1, 1:2, and 1:5, respectively. In conclusion, Icaritin were an active component. The inhibitory activity of Icariside II on pre-osteoclast RAW264.7 growth was synergized by Icaritin, which maybe contribute to the efficiency of Herba Epimedii extract on curing bone-related diseases, such as osteoporosis (C) 2014 Elsevier GmbH. All rights reserved.
关键词[WOS]: TOTAL FLAVONOIDS ;  KOREANUM NAKAI ;  IN-VITRO ;  GLYCOSIDES ;  DIFFERENTIATION ;  PROLIFERATION ;  OSTEOPOROSIS ;  TARGETS ;  LINES
语种: 英语
WOS记录号: WOS:000344241200016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144162
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Coll Inst Integrat Med, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

Recommended Citation:
Liu, Yan-Qiu,Yang, Qian-Xu,Cheng, Meng-Chun,et al. Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth[J]. PHYTOMEDICINE,2014,21(12):1633-1637.
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