DICP OpenIR
学科主题物理化学
Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation
Wang, Changsong1; Dong, Ran1; Wang, Xiaoyang1; Lian, Ailing1; Chi, Chunjie1; Ke, Chaofu2; Guo, Lei1; Liu, Shanshan1; Zhao, Wei1; Xu, Guowang3; Li, Enyou1; Li EY(李恩有)
刊名SCIENTIFIC REPORTS
2014-12-08
DOI10.1038/srep07312
4期:1页:07312
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GAS CHROMATOGRAPHY/MASS SPECTROMETRY ; SOLID-PHASE MICROEXTRACTION ; CELLS IN-VITRO ; BREATH ANALYSIS ; RELEASE ; MARKERS
英文摘要In this study, single-lung ventilation was used to detect differences in the volatile organic compound (VOCs) profiles between lung tissues in healthy and affected lungs. In addition, changes that occurred after lung cancer resection in both the VOCs profiles of exhaled breath from ipsilateral and contralateral lungs and the VOCs profiles of exhaled breath and blood sample headspaces were also determined. Eighteen patients with non-small cell carcinoma were enrolled. Alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. Solid phase microextraction-gas chromatography/mass spectrometry was used to assess the exhaled VOCs of the study participants. The VOCs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery, and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-Dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane, and hexadecane may be generated from lipid peroxidation during surgery. Caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer.
语种英语
WOS记录号WOS:000346272400001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144195
专题中国科学院大连化学物理研究所
通讯作者Li EY(李恩有)
作者单位1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Wang, Changsong,Dong, Ran,Wang, Xiaoyang,et al. Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation[J]. SCIENTIFIC REPORTS,2014,4(1):07312.
APA Wang, Changsong.,Dong, Ran.,Wang, Xiaoyang.,Lian, Ailing.,Chi, Chunjie.,...&李恩有.(2014).Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation.SCIENTIFIC REPORTS,4(1),07312.
MLA Wang, Changsong,et al."Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation".SCIENTIFIC REPORTS 4.1(2014):07312.
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