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学科主题: 物理化学
题名: Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation
作者: Wang, Changsong1;  Dong, Ran1;  Wang, Xiaoyang1;  Lian, Ailing1;  Chi, Chunjie1;  Ke, Chaofu2;  Guo, Lei1;  Liu, Shanshan1;  Zhao, Wei1;  Xu, Guowang3;  Li, Enyou1
通讯作者: 李恩有
刊名: SCIENTIFIC REPORTS
发表日期: 2014-12-08
DOI: 10.1038/srep07312
卷: 4, 期:1, 页:07312
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: In this study, single-lung ventilation was used to detect differences in the volatile organic compound (VOCs) profiles between lung tissues in healthy and affected lungs. In addition, changes that occurred after lung cancer resection in both the VOCs profiles of exhaled breath from ipsilateral and contralateral lungs and the VOCs profiles of exhaled breath and blood sample headspaces were also determined. Eighteen patients with non-small cell carcinoma were enrolled. Alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. Solid phase microextraction-gas chromatography/mass spectrometry was used to assess the exhaled VOCs of the study participants. The VOCs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery, and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-Dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane, and hexadecane may be generated from lipid peroxidation during surgery. Caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer.
关键词[WOS]: GAS CHROMATOGRAPHY/MASS SPECTROMETRY ;  SOLID-PHASE MICROEXTRACTION ;  CELLS IN-VITRO ;  BREATH ANALYSIS ;  RELEASE ;  MARKERS
语种: 英语
WOS记录号: WOS:000346272400001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144195
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China

Recommended Citation:
Wang, Changsong,Dong, Ran,Wang, Xiaoyang,et al. Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation[J]. SCIENTIFIC REPORTS,2014,4(1):07312.
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