DICP OpenIR
Subject Area物理化学
Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation
Wang, Changsong1; Dong, Ran1; Wang, Xiaoyang1; Lian, Ailing1; Chi, Chunjie1; Ke, Chaofu2; Guo, Lei1; Liu, Shanshan1; Zhao, Wei1; Xu, Guowang3; Li, Enyou1; Li EY(李恩有)
Source PublicationSCIENTIFIC REPORTS
2014-12-08
DOI10.1038/srep07312
Volume4Issue:1Pages:07312
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordGAS CHROMATOGRAPHY/MASS SPECTROMETRY ; SOLID-PHASE MICROEXTRACTION ; CELLS IN-VITRO ; BREATH ANALYSIS ; RELEASE ; MARKERS
AbstractIn this study, single-lung ventilation was used to detect differences in the volatile organic compound (VOCs) profiles between lung tissues in healthy and affected lungs. In addition, changes that occurred after lung cancer resection in both the VOCs profiles of exhaled breath from ipsilateral and contralateral lungs and the VOCs profiles of exhaled breath and blood sample headspaces were also determined. Eighteen patients with non-small cell carcinoma were enrolled. Alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. Solid phase microextraction-gas chromatography/mass spectrometry was used to assess the exhaled VOCs of the study participants. The VOCs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery, and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-Dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane, and hexadecane may be generated from lipid peroxidation during surgery. Caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer.
Language英语
WOS IDWOS:000346272400001
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144195
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi EY(李恩有)
Affiliation1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Wang, Changsong,Dong, Ran,Wang, Xiaoyang,et al. Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation[J]. SCIENTIFIC REPORTS,2014,4(1):07312.
APA Wang, Changsong.,Dong, Ran.,Wang, Xiaoyang.,Lian, Ailing.,Chi, Chunjie.,...&李恩有.(2014).Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation.SCIENTIFIC REPORTS,4(1),07312.
MLA Wang, Changsong,et al."Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation".SCIENTIFIC REPORTS 4.1(2014):07312.
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